Terminal zones of myelination
Updates to Article Attributes
Usually myelinationThe terminal zones of cerebral white matter becomes completemyelination are located at the age of 24 months.
Persistent high T2 signal patches may be seen surrounding the posterior aspect of the lateral ventricles (the peritrigonal regions) and are the only part of the cerebral white matter that may exhibit high T2 signal in a normal brain afterat 2 years of age, when myelination of cerebral white matter normally becomes complete. They appear
Radiographic features
MRI
-
T1 IR: low signal
in T1 inversion recovery sequence which has; better sensitivity than conventional T1 sequence. - T2: patches of high signal
Related pathology
Differentiation between these lesions and periventricular leukomalacia (PVLoutcomerelevance. Detection of normally myelinated low T2 signal white matter in-between the high signal patches and the lateral ventricle favors the diagnosis of terminal zone.
-<p>Usually myelination of cerebral white matter becomes complete at the age of 24 months.</p><p>Persistent high T2 signal patches may be seen surrounding the posterior aspect of lateral ventricles (the peritrigonal regions) in normal brain after 2 years of age. They appear low signal in T1 inversion recovery sequence which has better sensitivity than conventional T1 sequence.</p><p>Differentiation between these lesions and periventricular leukomalacia (<a href="/articles/periventricular-leukomalacia">PVL</a>) is important as the terminal zone has no clinical outcome. Detection of normally myelinated low T2 signal white matter in-between the high signal patches and the lateral ventricle favors the diagnosis of terminal zone.</p>- +<p>The <strong>terminal zones of myelination</strong> are located at the posterior aspect of the lateral ventricles (the peritrigonal regions) and are the only part of the cerebral white matter that may exhibit high T2 signal in a normal brain at 2 years of age, when myelination of cerebral white matter normally becomes complete.</p><h4>Radiographic features</h4><h5>MRI</h5><ul>
- +<li>
- +<strong>T1 IR:</strong> low signal; better sensitivity than conventional T1 sequence</li>
- +<li>
- +<strong>T2:</strong> patches of high signal</li>
- +</ul><h4>Related pathology</h4><p>Differentiation between these lesions and <a href="/articles/periventricular-leukomalacia">periventricular leukomalacia</a> (PVL) is important as the terminal zone has no clinical relevance. Detection of normally myelinated low T2 signal white matter in-between the high signal patches and the lateral ventricle favors the diagnosis of terminal zone.</p>
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