Traditional serrated adenoma
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A traditionalTraditional serrated adenoma (TSA)adenomas isare a formtype of premalignant serrated colonic polyp. They are a form of serrated polyp and considered a premalignant form.
Epidemiology
They are thoughthought to account for <1% of all colorectalcolonic polyps and 1-7% of all serrated lesions. They tend to occur in older patients (usually over 50 years) with no significant gender predilection.
Pathology
Many tend to be small (< 10 mm in size) and can be subclassified into BRAF and KRAS subtypes.
Location
They are found predominantly in the distal (left) colon with only rare occurrenceoccurrences in the proximal colon.
History and etymology
They were initially described by T A Longacre et al. in 1990 2.
-<p>A <strong>traditional serrated adenoma (TSA) </strong>is a form of <a href="/articles/colon-polyp">colonic polyp</a>. They are a form of <a href="/articles/serrated-polyp">serrated polyp</a> and considered a premalignant form..</p><h4>Epidemiology</h4><p>They are though to account for <1% of all colorectal polyps and 1-7% of all serrated lesions. They tend to occur in older patients (usually over 50 years) with no significant gender predilection.</p><h4>Pathology</h4><p>Many tend to be small (< 10 mm in size) and can be subclassified into BRAF and KRAS subtypes.</p><h5>Location</h5><p>They are found predominantly in the distal (left) colon with only rare occurrence in the proximal colon.</p><h4>History and etymology</h4><p>They were initially described by <strong>T A Longacre et al</strong>. in 1990 <sup>2</sup></p>- +<p><strong>Traditional serrated adenomas </strong>are a type of premalignant serrated <a href="/articles/colon-polyp" title="Colonic polyp">colonic polyp</a>.</p><h4>Epidemiology</h4><p>They are thought to account for <1% of all colonic polyps and 1-7% of all serrated lesions. They tend to occur in older patients (usually over 50 years) with no significant gender predilection.</p><h4>Pathology</h4><p>Many tend to be small (< 10 mm in size) and can be subclassified into BRAF and KRAS subtypes.</p><h5>Location</h5><p>They are found predominantly in the distal (left) <a href="/articles/large-intestine-1" title="Colon">colon</a> with only rare occurrences in the proximal colon.</p><h4>History and etymology</h4><p>They were initially described by <strong>T A Longacre et al</strong>. in 1990 <sup>2</sup>.</p>
References changed:
- 3. Bateman A. The Spectrum of Serrated Colorectal Lesions-New Entities and Unanswered Questions. Histopathology. 2021;78(6):780-90. <a href="https://doi.org/10.1111/his.14305">doi:10.1111/his.14305</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/33332664">Pubmed</a>
- 3. Bateman A. The Spectrum of Serrated Colorectal Lesions—new Entities and Unanswered Questions. Histopathology. 2021;78(6):780-90. <a href="https://doi.org/10.1111/his.14305">doi:10.1111/his.14305</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/33332664">Pubmed</a>
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