Trastuzumab deruxtecan related interstitial lung disease

Last revised by Yuranga Weerakkody on 21 Dec 2023

Trastuzumab deruxtecan related interstitial lung disease (T-Dxd ILD) is a form of drug induced lung disease which can rarely occur with the antibody-drug conjugate trastuzumab deruxtecan (T-DXd).

It can cause a fatal pneumonitis and therefore its recognition is important.

Radiographic features

CT

Several patterns have been described which include 2

A subset of cases with COP pattern demonstrated an atypical distribution with upper and peripheral lung involvement (~ 9%).

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