Vigabatrin-associated toxicity

Last revised by Rohit Sharma on 21 Feb 2024

Vigabatrin-associated toxicity is a potential neurological complication in patients treated with vigabatrin, an antiseizure medication whose mechanism of action includes GABA levels retention at the level of synapses in the brain. It is primarily used as a treatment of focal seizures and infantile spasm disorders. The potential for brain abnormalities to develop during treatment is well recognized 1.

Patients with vigabatrin-associated toxicity typically experience visual disturbances.

Hyperintense signal on T2, FLAIR, and DWI sequences are present in the basal ganglia, thalamus, and brainstem 1,2.

These changes are resolved upon the cessation of therapy 2.

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