V/Q (ventilation/perfusion) scan is a scintigraphic examination of the lung that evaluates pulmonary vasculature perfusion and segmental bronchoalveolar tree ventilation.
- diagnosis of suspected pulmonary embolism
- monitor pulmonary function following lung transplant
- provide preoperative estimates of lung function in lung cancer patients, where pneumonectomy is planned
The ventilation scan performed using radio-isotope labeled aerosols like technetium-99m DTPA delivered to the patient through a non-rebreathing mask, with the patient supine. The micro-aerosol particles are small enough to reach the distal tracheobronchial tree and reflect regional ventilation 1. The patient is then imaged in the upright position in three phases: initial breath, equilibrium and washout.
The perfusion lung scan involves injecting Tc-99m MAA intravenously in the supine position. The MAA particles are just small enough to get lodged in the pre-capillary arterioles. A high resolution, large field of view gamma camera is used to image the lungs.
Interpretive criteria developed from the PIOPED, PIOPED II, or PISAPED trials can be used to determine the probability of a pulmonary embolism on a V/Q scan. For the diagnosis of PE, a V/Q scan has a reported sensitivity of 77.4% and specificity of 97.7% when compared to CT pulmonary angiography (CTPA) or digital subtraction angiography (DSA) 3.
A normal ventilation scan (even distribution of radionuclide throughout the lung fields) with multiple, bilateral perfusion defects are the classical findings of pulmonary embolism 1.
Causes of ventilation/perfusion mismatch include:
- acute pulmonary embolism
- chronic pulmonary embolism
- obstruction of an artery by a tumor 2
- radiation therapy 2
The presence of a right-to-left shunt can be assessed by searching for evidence of renal or brain activity.
- 1. Brant WE, Helms C. Fundamentals of Diagnostic Radiology. LWW. ISBN:1608319113. Read it at Google Books - Find it at Amazon
- 2. Parker JA, Coleman RE, Grady E et-al. SNM practice guideline for lung scintigraphy 4.0. J Nucl Med Technol. 2012;40 (1): 57-65. doi:10.2967/jnmt.111.101386 - Pubmed citation
- 3. Sostman HD, Stein PD, Gottschalk A, Matta F, Hull R, Goodman L. Acute pulmonary embolism: sensitivity and specificity of ventilation-perfusion scintigraphy in PIOPED II study. (2008) Radiology. 246 (3): 941-6. doi:10.1148/radiol.2463070270 - Pubmed