WHO grading system for diffuse astrocytomas

Dr Varun Babu and A.Prof Frank Gaillard et al.

 The WHO grading system is the most widely used system for grading diffuse astrocytomas (at the time of writing i.e. mid 2016), and is an adaptation of the now superseded  St Anne-Mayo grading system (also known as the Daumas-Duport grading system). 

Grade I is reserved for localised astrocytomas (see WHO classification of CNS tumours for a complete list) and as such diffuse astrocytomas range in grade from grade II to IV. 

Gliomatosis cerebri does not have its own grade, but rather is a highly infiltrative version of a low grade or anaplastic tumour which involves at least three lobes 5. It does however confer a worse prognosis. 

It is worth noting that there are other grading systems (see diffuse astrocytoma grading) and the pros and cons of each have been the subject of extensive debate. 

Astrocytic tumour
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rID: 23710
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