Tuberculosis - Right upper lobe cavitation

Case contributed by Frank Gaillard
Diagnosis certain

Presentation

Cough.

Patient Data

Age: 30 years
Gender: Female

Extensive cavitating nodular opacities in the right upper lobe, with a large cavity measuring 4cm in diameter. There are multiple nodules also seen in the left upper lobe. Wide right paratracheal stripe possibly due to lymphadenopathy.

The appearances are highly suspicious for pulmonary TB.

Case Discussion

The patient went on to have bronchial washings confirming pulmonary tuberculosis

Microscopy

  • Auramine-Rhodamine Stain: +++ (> 10 Acid fast bacilli detected per HPF)
  • Ziehl-Neelsen Stain: +++ (> 10 Acid fast bacilli detected per HPF)

Microbiology

  • Mycobacterial culture: Mycobacterium tuberculosis = isolated
  • M.tuberculosis Complex PCR = detected
  • MPT64 Antigen Identification Test: M.tuberculosis Complex = detected

Sensitivities: 

  • Ethambutol = sensitive
  • Isoniazid = sensitive
  • Pyrazinamide = sensitive
  • Rifampin = sensitive

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