Beta thalassaemia major - Cooley anaemia

Case contributed by Dr Chris O'Donnell

Presentation

Acute knee injury with medial pain. ?medial meniscal injury.

Patient Data

Age: 45 years
Gender: Male

Reversal of normal marrow signal seen as predominantly bright PD fat sat and dark T1 signal, indicating conversion of yellow to red marrow. Exaggerated trabeculae and slight bone expansion.

Haemopoietic expansion results in abnormal high signal intensity marrow on the PD FS and T2 FS sequences. Normal signal in the patella, indicating it contains normal yellow marrow and normal trabeculae.

This lateral radiograph of the lumbar spine was on PACS (no mention of underlying diagnosis in the clinical notes). For a 45-year-old the vertebrae are porotic with prominent vertical trabeculations typical of thalassaemia.

Case Discussion

Both the plain film and MRI demonstrate prominence of trabecular striations which is seen in thalassaemia. The diagnosis of beta thalassaemia was confirmed with the clinician.

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Case information

rID: 16592
Published: 1st Feb 2012
Last edited: 16th Jul 2018
Inclusion in quiz mode: Included

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