Cerebellar metastasis - from ovarian cancer
Known ovarian carcinoma.
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Irregularly enhancing, mainly peripherally, mass lesion, in the posterior fossa on the left side, with mass effect on the fourth ventricle and brain stem resulting in hydrocephalus. Significant surrounding hypodensity, most in keening vasogenic edema.
Cerebellum: Metastatic carcinoma, moderately to poorly differentiated, consistent with metastatic adenocarcinoma (serous) of ovarian origin.
Clinical History as Provided by Submitting Physician:
Known ovarian Ca
Sections show cerebellar tissue extensively infiltrated by metastatic moderately to poorly differentiated carcinoma. Areas of extensive tumour necrosis are seen, and a pseudo-papillary pattern is evident focally. The tumour cells are otherwise arranged in sheets and are characterized by relatively large cells with moderate amounts of amphophilic to eosinophilic cytoplasm. Increased nuclear pleomorphism is evident, nucleoli are generally prominent. Mitotic activity is significantly elevated.