Endometrial polyp with complex hyperplasia and atypia (Pathology)
Diagnosis certain
Updates to Study Attributes
Findings
was changed:
The sections consist of background endometrium displaying changes of cystic atrophy. Several fragments have a polypoid appearance, which in areas show an increased gland-to-stroma ratio and a spindled, fibrous stroma. Focally, the glandular architecture is crowded, with complex cribriform patterns. These glands display cellular stratification and crowding, with pleomoprhic, enlarged nuclei showing coarse chromatin, prominent nucleoli and scattered mitotic figures.
Note: No evidence of malignancy was present within the tissue sampled.
Legends for individual slides:
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Background20x H&E-
background endometrium with changes of cystic atrophy
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background endometrium with changes of cystic atrophy
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Background40x H&E-
background endometrium
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background endometrium
Cystically dilated glands with tubal metaplasia.
100x H&ELow-power view of polyp - smooth rounded outline covered in epithelium, with increased numbers of glands compared to the background endometrium.Glands show varying degrees of crowding, set within a fibrous, spindled stroma containing scattered vessels.-
Mostmost glands maintain simple tubular outlines, whilst occasional glands show a more complex and cribriform architecture. There -
there is no back-to-back gland formation
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Crowded100x H&E-
crowded glands with complex architecture
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crowded glands with complex architecture
- lining epithelium shows nuclear stratification, with enlarged, irregular nuclei, elevated nuclear: cytoplasmic ratios, and coarse chromatin. Increased numbers of mitotic figures are present
- the same cytological atypia is present in glands with both simple and complex architecture
- lining epithelium shows nuclear stratification, with enlarged, irregular nuclei, elevated nuclear: cytoplasmic ratios, and coarse chromatin
- increased numbers of mitotic figures are present
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