Focal cortical dysplasia - bottom of sulcus
- Biogen Australia Pty Ltd, Investigator-Initiated Research Grant for CAD software in multiple sclerosis: finished Oct 2021 (past)
Updates to Study Attributes
A subtle high FLAIR transmantle band extends to the bottom of a small sulcus arising from the right post central-central gyrus just behind the central sulcus (best seen on coronal FLAIR image 56/57). . This lies 1.5 cm above the Sylvian fissure. Definite No definite cortical thickening or appearing of theabnormal grey-white matter interface is not to visualised however the.
Incidental left-sided frontal development venous anomaly.
Conclusion:
Overall, appearances may reflect the possibility offavour a bottom of a sulcus dysplasia (at the limit of MRI resolution). The site correlates with the focal region of interictal FDG PET hypometabolism (not shown).
Image MRI (FLAIR) ( update )
![](https://prod-images-static.radiopaedia.org/images/52027685/bf7aefb7b12f498484a7e1191c261cc3352eee013c38218a163320494b0d8e45_thumb.jpeg)
Image 8 MRI (FLAIR) ( create )
![](https://prod-images-static.radiopaedia.org/images/52027700/04cbefad4cbfe43a2c25bcf95c83d7_thumb.jpeg)
Image 57 MRI (FLAIR) ( create )
![](https://prod-images-static.radiopaedia.org/images/52027569/94027f9933a7eab74a8425cff1d8b3_thumb.jpeg)
Updates to Case Attributes
The patient went on to have epilepsy surgery.
Histopathology with resection of the resected lesion as follows:
"MICROSCOPIC DESCRIPTION
this region of cortex.
Histology
Sections show portions of cerebral cortex demonstrating dyslamination and frequent dysmorphic neuronsneurones with abnormally distributed Nissl substance, vacuolated cytoplasm and enlarged nuclei. Occasional balloon cells are present with glassy eosinophilic cytoplasm. There is background reactive astrocytosis. A few heterotopic white matter neuronsneurones are seen. There is no evidence of a neoplastic process.
On immunohistochemistry, maloriented/dysmorphic neuronsneurones are highlighted with NeuN, NF and synaptophysin. Reactive astrocytosis is highlighted with GFAP. The ballooned cells are positive for GFAP, NF and synaptophysin.
CONCLUSION
Final diagnosis
Right parietal tissue - : focal cortical dysplasia, type IIb."
The patient remains seizure free at last follow-up.
-The patient went on to have epilepsy surgery.--Histopathology of the resected lesion as follows:-"MICROSCOPIC DESCRIPTION-Sections show portions of cerebral cortex demonstrating dyslamination and frequent dysmorphic neurons with abnormally distributed Nissl substance, vacuolated cytoplasm and enlarged nuclei. Occasional balloon cells are present with glassy eosinophilic cytoplasm. There is background reactive astrocytosis. A few heterotopic white matter neurons are seen. There is no evidence of a neoplastic process.-On immunohistochemistry, maloriented/dysmorphic neurons are highlighted with NeuN, NF and synaptophysin. Reactive astrocytosis is highlighted with GFAP. The ballooned cells are positive for GFAP, NF and synaptophysin.-CONCLUSION-Right parietal tissue - focal cortical dysplasia, type IIb."--The patient remains seizure free at last follow-up.- +<p>The patient went on to have epilepsy surgery with resection of this region of cortex. </p><p><strong>Histology</strong></p><p>Sections show portions of cerebral cortex demonstrating dyslamination and frequent dysmorphic neurones with abnormally distributed Nissl substance, vacuolated cytoplasm and enlarged nuclei. Occasional balloon cells are present with glassy eosinophilic cytoplasm. There is background reactive astrocytosis. A few heterotopic white matter neurones are seen. There is no evidence of a neoplastic process. </p><p>On immunohistochemistry, maloriented/dysmorphic neurones are highlighted with NeuN, NF and synaptophysin. Reactive astrocytosis is highlighted with GFAP. The ballooned cells are positive for GFAP, NF and synaptophysin. </p><p><strong>Final diagnosis</strong></p><p>Right parietal tissue: <a href="/articles/focal-cortical-dysplasia" title="Focal cortical dysplasia">focal cortical dysplasia</a>, type IIb. </p><p>The patient remains seizure free at last follow-up.</p>