Presentation
Dizziness.
Patient Data
Left posteromedial temporal lesion, involving the most posterior parts of the parahippocampal and cingulate gyrus and extending into the splenium of the corpus callosum. It shows heterogeneous signal with large necrotic center and marginal contrast enhancement. The lesion is surrounded by extensive vasogenic edema signal involving the splenium of the corpus callosum.
Based on radiological findings, high grade glioma was considered.
Pathology after excision revealed a glioblastoma (grade 4).
IDH 1 mutation testing was not performed.
Case Discussion
Glioblastomas are typically large tumors at diagnosis. They often have thick, irregular-enhancing margins and a central necrotic core, which may also have a hemorrhagic component. They are surrounded by vasogenic-type edema, which in fact usually contains infiltration by neoplastic cells.
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