Hot nose sign - brain death

Case contributed by Dr Andrew Dixon


Motor bike accident. ?brain death

Patient Data

Age: 30 years
Gender: Male
Nuclear medicine

Figure 1: Tc-99m HMPAO Brain Perfusion Scan

Figure 1A & B: Tc-99m HMPAO scan shows absent cerebral perfusion consistent with brain death. Relatively increased nasal region perfusion due to preserved external carotid artery flow is often termed the 'hot nose sign'. 

Annotated image

Figure 2

Case Discussion

Hot nose sign  - an indirect sign of brain death on nuclear medicine cerebral perfusion studies. Absence of internal carotid artery flow leads to increased external carotid artery flow and subsequent increased perfusion in the nasal region. Although the sign is cute, it is not of any real diagnostic value as the medico-legal importance of brain death is such that direct assessment of cerebral perfusion is required.1 

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Case information

rID: 19410
Case created: 5th Sep 2012
Last edited: 31st May 2017
Inclusion in quiz mode: Included

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