Medulloblastoma - adult

CT demonstratesThere is a mixed solid and cystic mass surrounded by peritumoural oedema within the left cerebellar hemisphere. Is is composed of mixed solid and cystic components and is surrounded by tumour oedema.

The solid component appears slightly hyperdense. Following administration of contrast, vivid enhancement of the solid component is present.

MRI demonstrates a mass within the left cerebellar hemisphere. IsIt is composed of mixed solid and cystic components and is surrounded by a mantle of tumourwith peritumoural oedema.

The solid component demonstrates demonstrates restricted diffusion on DWI. Following administration of contrast, vivid and avid enhancement of the solid component is presentpost contrast administration.

The differential is of a haemangioblastoma, high grade glioma, a metastasis or of an adult medulloblastoma. The hypderdensity, exceticexccentric location, and restricted diffusion are all consistent with the latter,confirmed confirmed at pathology. 

Histology

Microscopic Description:

Sections show a highly cellular tumour mass composed of cells with hyperchromatic oval nuclei and little visible cytoplasm. The nuclei have coarsely clumped chromatin and inconspicuous nucleoli. Mitotic activity and individual cell necrosis and apoptosis are frequent. In some areas, the nuclei show a tendency to mold to one another. The cells are arranged in solid disorganized sheets and in small lobules and columns separated by collagenous septa. Multiple small cystic spaces are present but there is no geographic necrosis. One small fragment of recognizable cerebellar cortex is present and shows diffuse infiltration by neoplastic cells. Immunohistochemistry shows diffuse cytoplasmic reactivity for NSE and synaptophysin and occasional cells are positive for GFAP and S-100. The tumour is negative for cytokeratin, LCA, HMB-45 and Mel A.

Final diagnosis: Medulloblastoma