Olfactory neuroblastoma (esthesioneuroblastoma)

Case contributed by Assoc Prof Frank Gaillard


Case Discussion



The sections show fragments of dense hyalinised collagen with prominent bundles of myelinated nerve fibers. There is extensive infiltration of the tissue fragments by a densely hypercellular tumor. This is composed of cells with small round, oval and angulated nuclei and a small amount of eosinophilic cytoplasm. These are dispersed in irregularly shaped anastomosing islands and cords. Frequent mitotic figures are noted. No necrosis is identified. Focal perineurial infiltration by tumor is noted. Tumor cells show strong cytoplasmic immunostaining for neuron specific enolase (NSE) and synaptophysin. The features are of esthesioneuroblastoma (olfactory neuroblastoma)

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Case information

rID: 9065
Published: 15th Mar 2010
Last edited: 13th Aug 2019
System: Head & Neck
Inclusion in quiz mode: Included

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