Physiological uptake of Ga-68 DOTATATE at the uncinate process of pancreas

Case contributed by Bruno Di Muzio , 13 Sep 2017
Diagnosis almost certain
Changed by Mark Thurston, 14 Sep 2017

Updates to Case Attributes

Age changed from 52 years to 50 years.
Body was changed:

This case illustrates part of the imaging work up for a neuroendocrine tumour. CT Chestchest, Abdomenabdomen, and pelvis and GaTate (gallium-68 DOTA-TATE) PET/CT were normal with no underlying carcinoid tumour. 

The increased uptake seen in the pancreatic head is a recognised physiological finding that happens in some of the scans and should be interpreted with caution. SUV quantification is advised to avoid false positives, as the physiological uptake is similar to the uptake in the liver (uptake ratio head to liver SUVav < 1.4) 1.

The 5-HIAA was only mildly elevated in this patient and, in the context of a normal of GaTate PET/CT, carcinoid syndrome was considered unlikely to explain the patient's symptoms (flushing and diarrhoea). 

  • -<p>This case illustrates part of the imaging work up for a neuroendocrine tumour. CT Chest, Abdomen, and pelvis and GaTate PET/CT were normal with no underlying carcinoid tumour. </p><p>The increased uptake seen in the pancreatic head is a recognised physiological finding that happens in some of the scans and should be interpreted with caution. SUV quantification is advised to avoid false positives, as the physiological uptake is similar to the uptake in the liver (uptake ratio head to liver SUVav &lt; 1.4) <sup>1</sup>.</p><p>The 5-HIAA was only mildly elevated in this patient and, in the context of a normal of GaTate PET/CT, carcinoid syndrome was considered unlikely to explain the patient's symptoms (flushing and diarrhoea). </p>
  • +<p>This case illustrates part of the imaging work up for a neuroendocrine tumour. CT chest, abdomen, and pelvis and GaTate (gallium-68 DOTA-TATE) PET/CT were normal with no underlying carcinoid tumour. </p><p>The increased uptake seen in the pancreatic head is a recognised physiological finding that happens in some of the scans and should be interpreted with caution. SUV quantification is advised to avoid false positives, as the physiological uptake is similar to the uptake in the liver (uptake ratio head to liver SUVav &lt; 1.4) <sup>1</sup>.</p><p>The 5-HIAA was only mildly elevated in this patient and, in the context of a normal of GaTate PET/CT, carcinoid syndrome was considered unlikely to explain the patient's symptoms (flushing and diarrhoea). </p>

Updates to Study Attributes

Findings was changed:

No focal abnormal uptake is seen in the small bowel or pancreas. No abnormal uptake is seen in the lung fields. No nodal or distant metastases.

Further findings: Physiologicphysiologic uptake is seen in the uncinate process of the pancreas. There is a symmetric uptake in the partially calcified mediastinal and hilar lymph nodes representing reactive aetiology. The distribution of radiotracer elsewhere is physiologic.

How to use cases

You can use Radiopaedia cases in a variety of ways to help you learn and teach.

Creating your own cases is easy.

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.