Presentation
Lump right testis. Tumor markers negative.
Patient Data
Circumscribed but unencapsulated tumor with heterogenous cut surface (including areas of congestion and necrosis), replacing much of the testicular parenchyma but confined to the testis macroscopically.
1. Low power histology showing circumscribed but unencapsulated tumor with adjacent normal seminiferous tubules (lower left)
2. Sheets of tumor cells, most with medium sized nuclei but with scattered cells showing markedly enlarged rounded nuclei. There is only limited background stroma with patchy hemorrhage.
3. Scattered cells with large nuclei and coarse chomatin
4. Negative OCT3/4 immunohistochemical stain
Case Discussion
Spermatocytic tumor (formally spermatocytic seminoma) is a rare form of germ cell tumor.
In contrast to classical seminoma, it tends to occur in older men (mean age 50+) and does not arise from conventional 'precursor' (germ cell neoplasia in-situ). The tumor cells are negative for OCT3/4 (embryonic stem cell regulating gene).
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