Thalidomide embryopathy
Diagnosis certain
Disclosures
- updated 8 Sep 2023:
Nothing to disclose
Updates to Study Attributes
Findings
was changed:
Obvious skeletal malformation of the upper distal limb - known history of thalidomidesuch as (phocomelia), radial ray anomalies with markedly hypoplastic radius, absent thumb and carpal bones, hypoplatic curved ulna and ulnar-metacarpal fusion.
Images Changes:
Image X-ray (Oblique) ( update )
Perspective
changed from AP/Oblique to Oblique.
Image X-ray (Frontal) ( update )
Perspective
changed from DP to Frontal.
Image 1 X-ray (Oblique) ( create )
Annotation 4446
changed from ,0 arrows,0 labels to ulnar-metacarpal fusion,1 arrow,1 label.
Image 1 X-ray (Oblique) ( create )
Annotation 4447
changed from ,0 arrows,0 labels to hypoplatic ulna ,1 arrow,1 label.
Image 1 X-ray (Frontal) ( create )
Annotation 4448
changed from ,0 arrows,0 labels to markedly hypoplastic radius,1 arrow,1 label.
Image 1 X-ray (Frontal) ( create )
Annotation 4449
changed from ,0 arrows,0 labels to absent thumb,1 arrow,1 label.
Image 1 X-ray (Frontal) ( create )
Annotation 4450
changed from ,0 arrows,0 labels to carpal bones,2 arrows,1 label.
Updates to Case Attributes
Body
was changed:
Obvious skeletal malformation of the upper distal limb - known history of thalidomide.
The illness known as thalidomide embryopathy, which is caused by in utero exposure to the drug, is distinguished by a number of foetal malformations. The majority of thalidomide exposure in foetuses happened between 1957 and 1961, when it was prescribed to pregnant women to relieve morning sickness.
It can lead to limb, facial and cardiac abnormalities or limited growth.
-<p>Obvious skeletal malformation of the upper distal limb - known history of <a href="/articles/thalidomide-embryopathy" title="Thalidomide embryopathy">thalidomide</a></p>- +<p>Obvious skeletal malformation of the upper distal limb - known history of <a href="/articles/thalidomide-embryopathy" title="Thalidomide embryopathy">thalidomide</a>.</p><p>The illness known as thalidomide embryopathy, which is caused by in utero exposure to the drug, is distinguished by a number of foetal malformations. The majority of thalidomide exposure in foetuses happened between 1957 and 1961, when it was prescribed to pregnant women to relieve morning sickness.</p><p>It can lead to limb, facial and cardiac abnormalities or limited growth.</p>
References changed:
- 1. Vargesson N, Hooper G, Giddins G, Hunter A, Stirling P, Lam W. Thalidomide Upper Limb Embryopathy - Pathogenesis, Past and Present Management and Future Considerations. J Hand Surg Eur Vol. 2023;48(8):699-709. <a href="https://doi.org/10.1177/17531934231177425">doi:10.1177/17531934231177425</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/37226469">Pubmed</a>
- 1. Vargesson N, Hooper G, Giddins G, Hunter A, Stirling P, Lam W. Thalidomide Upper Limb Embryopathy – Pathogenesis, Past and Present Management and Future Considerations. J Hand Surg Eur Vol. 2023;48(8):699-709. <a href="https://doi.org/10.1177/17531934231177425">doi:10.1177/17531934231177425</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/37226469">Pubmed</a>
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