Search results for “multiple sclerosis”
143 results found
Article
Multiple sclerosis
Multiple sclerosis (MS) is a relatively common acquired chronic demyelinating disease involving the central nervous system, and is the second most common cause of neurological impairment in young adults, after trauma 19. Characteristically, and by definition, multiple sclerosis is disseminated i...
Article
Multiple sclerosis (summary)
This is a basic article for medical students and other non-radiologists
Multiple sclerosis (MS) is a chronic demyelinating condition affecting the central nervous system. Diagnosis requires good history, clinical examination, appropriate imaging, and laboratory tests (cerebrospinal fluid for Ig...
Article
Tumefactive multiple sclerosis
Tumefactive multiple sclerosis is a term used to describe patients with established multiple sclerosis who develop large aggressive demyelinating lesions, similar/identical in appearance to those seen in sporadic tumefactive demyelinating lesions (TDL). TDL is now considered to be a separate ent...
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Opticospinal multiple sclerosis
Opticospinal multiple sclerosis (OSMS) is a demyelinating disease and has been considered a variant of multiple sclerosis (MS) encountered in Asian populations, who are generally rarely affected by normal multiple sclerosis. It has similar clinical and imaging features to neuromyelitis optica (N...
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Marburg variant of multiple sclerosis
The Marburg variant of multiple sclerosis, also known as acute, fulminant, or malignant multiple sclerosis, is characterized by extensive and fulminant acute demyelination, often resulting in death within one year after the onset of clinical signs.
Please, refer to the main multiple sclerosis (...
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Schilder type multiple sclerosis
Schilder disease, also known as diffuse myelinoclastic sclerosis or diffuse cerebral sclerosis, is considered a variant of multiple sclerosis, and represents an extremely rare progressive demyelinating process that begins in childhood 1,4.
Epidemiology
The disease is extremely rare with less ...
Article
Uhthoff phenomenon (multiple sclerosis)
Uhthoff phenomenon refers to the temporary exacerbation (lasting less than 24 hours) of neurological symptoms secondary to increases in body temperature. This phenomenon is experienced by multiple sclerosis patients, though it also occurs in other demyelinating diseases 1.
History and etymolog...
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McDonald diagnostic criteria for multiple sclerosis
McDonald diagnostic criteria for multiple sclerosis are clinical, radiographic, and laboratory criteria used in the diagnosis of multiple sclerosis. They were originally introduced in 2001 and revised multiple times (see "previous versions" below) most recently in 2017 5.
Criteria
The diagnos...
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MAGNIMS consensus on MRI diagnosis of multiple sclerosis
The magnetic resonance imaging in multiple sclerosis (MAGNIMS), which is a European collaborative research network, published in 2016 new recommendations to upgrade the imaging diagnosis criteria for multiple sclerosis (MS). These came as a consensus, based on evidence-based and expert opinions ...
Article
Central vein sign
The central vein sign is a marker for multiple sclerosis (MS) and is the imaging manifestation of the perivenular nature of demyelinating plaques. It is not pathognomonic but can be useful in helping differentiate multiple sclerosis from mimics, such as cerebral small vessel disease, neuromyelit...
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Ependymal dot-dash sign
The ependymal dot-dash sign has been described as an early MRI imaging feature of multiple sclerosis before other more florid white matter changes (e.g. Dawson's fingers) become evident 1. It has also been suggested as a feature that can be used to distinguish multiple sclerosis from neuromyelit...
Article
Acute disseminated encephalomyelitis (ADEM)
Acute disseminated encephalomyelitis (ADEM), as the name would suggest, is featured by a monophasic acute inflammation and demyelination of white matter typically following a recent (1-2 weeks prior) viral infection or vaccination 4,6. Grey matter, especially that of the basal ganglia, is also o...
Article
Tumefactive demyelinating lesion
Tumefactive demyelinating lesion (TDL), also sometimes referred to as monofocal acute inflammatory demyelination (MAID), is a locally aggressive form of demyelination, usually manifesting as a solitary lesion (or sometimes a couple of lesions) greater than 2 cm that may mimic a neoplasm on imagi...
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Radiologically isolated syndrome
Radiologically isolated syndrome (RIS) is defined by MRI findings meeting the McDonald criteria for multiple sclerosis in the brain and/or spinal cord in asymptomatic patients. Radiological progression usually occurs in approximately 66% of patients with RIS, while ~33% per 5-year-period will su...
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Neuromyelitis optica spectrum disorder
Neuromyelitis optica spectrum disorder (NMOSD) is a severe demyelinating diseases, which in seropositive cases, is caused by an autoantibody to the aquaporin-4 water channel. The classic presentation of NMOSD is with the triad of optic neuritis, longitudinally extensive myelitis, and positive an...
Article
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD)
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) represents a group of inflammatory demyelinating disorders united by the presence of IgG antibodies to myelin oligodendrocyte glycoprotein (MOG). It is becoming increasingly evident that MOGAD represents a distinct clinical...
Article
Optic neuritis
Optic neuritis denotes inflammation of the optic nerve and is one of the more common causes of optic neuropathy. It can be thought of as broadly divided into infectious and non-infectious causes, although the latter is far more frequent. On imaging, optic neuritis is most easily identified as a ...
Article
Baló concentric sclerosis
Baló concentric sclerosis is a rare and severe monophasic demyelinating disease, considered a subtype of multiple sclerosis, appearing as a rounded lesion with alternating layers of high and low signal intensity on MRI, giving it a characteristic 'bullseye' or 'onion bulb' appearance 1,9.
Epide...
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Trigeminal neuralgia
Trigeminal neuralgia, also known as tic douloureux, corresponds to a clinical manifestation of sudden severe paroxysms of excruciating pain on one side of the face which usually lasts a few seconds to a few minutes, involving one or more branches of the trigeminal nerve (CN V). Neurovascular com...
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Demyelination protocol (MRI)
MRI protocol for demyelinating diseases is a group of MRI sequences put together to best approach these white matter disorders characterized by the destruction or damage of normally myelinated structures. These disorders may be inflammatory, infective, ischemic or toxic in origin.
Historically...
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