Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Lausen T, Bell D, et al. Hyperthermic intraperitoneal chemotherapy. Reference article, Radiopaedia.org (Accessed on 05 Jun 2024) https://doi.org/10.53347/rID-83274
Hyperthermic intraperitoneal chemotherapy (often abbreviated as HIPEC) is a form of chemotherapy used for the treatment of peritoneal involvement with malignancy.
It usually involves the instillation of heated (to around 41–43°C) chemotherapy agents directly into the abdominopelvic cavity immediately after surgery. It delivers a high dose directly to the site of potential residual microscopic cancer cells while minimizing systemic toxicity. Heating to this temperature is thought to increase drug penetration and cytotoxicity.
The patient can be gently rocked during the procedure to ensure maximum dispersion of the chemotherapy throughout the cavity. It is typically instilled for around 60–90 minutes and then drained.
See also
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1. Valle SJ, Alzahrani NA, Liauw W, et al. Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Methodology, Drugs and Bidirectional Chemotherapy. (2016) Indian journal of surgical oncology. 7 (2): 152-9. doi:10.1007/s13193-016-0498-0 - Pubmed
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2. Goodman MD, McPartland S, Detelich D, Saif MW. Chemotherapy for intraperitoneal use: a review of hyperthermic intraperitoneal chemotherapy and early post-operative intraperitoneal chemotherapy. (2016) Journal of gastrointestinal oncology. 7 (1): 45-57. doi:10.3978/j.issn.2078-6891.2015.111 - Pubmed
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3. Emily A. Aherne, Helen M. Fenlon, Conor J. Shields, Jurgen J. Mulsow, Carmel G. Cronin. What the Radiologist Should Know About Treatment of Peritoneal Malignancy. (2017) American Journal of Roentgenology. 208 (3): 531-543. doi:10.2214/AJR.16.16646 - Pubmed
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4. Durot C et.al. What the radiologist should know about postoperative MDCT evaluation of a patient treated with cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy. (2018) Clinical radiology. doi:10.1016/j.crad.2018.02.001 - Pubmed
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5. Low RN. Preoperative and surveillance MR imaging of patients undergoing cytoreductive surgery and heated intraperitoneal chemotherapy. (2016) Journal of gastrointestinal oncology. 7 (1): 58-71. doi:10.3978/j.issn.2078-6891.2015.115 - Pubmed
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