Bartter syndrome is a rare inherited renal disorder.
Bartter syndrome is characterized by hyperplasia of the juxtaglomerular cells along with:
- metabolic alkalosis
- elevated plasma renin
- elevated aldosterone
- antenatal polyhydramnios
There are two subtypes of Bartter syndrome:
- classic: presents in early childhood with polyuria, polydipsia with a predisposition to dehydration
- neonatal: presents earlier
History and etymology
First described in 1962 by American endocrinologist Frederic Crosby Bartter (1914-1983) 3.
- 1. Vieira H, Mendes L, Mendes P et-al. Classic Bartter syndrome: a rare cause of failure to thrive in a child. BMJ Case Rep. 2012;2012 (jun28 1): . doi:10.1136/bcr.02.2012.5888 - Free text at pubmed - Pubmed citation
- 2. Cunha TDS, Heilberg IP. Bartter syndrome: causes, diagnosis, and treatment. (2018) International journal of nephrology and renovascular disease. 11: 291-301. doi:10.2147/IJNRD.S155397 - Pubmed
- 3. Wilson JD, Delea CS. Frederic C. Bartter: September 10, 1914-May 5, 1983. (1990) Biographical memoirs. National Academy of Sciences (U.S.). 59: 3-24. Pubmed