Choline peak
Updates to Article Attributes
Body
was changed:
Choline is a precursor of acetylcholine (ACH), a component of cell membranes which is commonly examined in MR spectroscopy. It resonates at 3.2 ppm chemical shift. Infant’s brain shows - for active myelination with synthesis of membrane constituents - high choline signals 3-5-6.
Choline is a marker of cellular membrane turnover and therefore elevated in neoplasms, demyelination, inflammation and gliosis 1.
It is useful in a number of scenarios:
- diffuse glioma vs. metastasis: elevation in a region of high T2 signal surrounding an enhancing mass (oedema) suggests an infiltrating diffuse glioma rather than a cerebral metastasis
- GBM progression vs. pseudoprogression: elevation favours tumour progression over pseudoprogression, but can be elevated if a strong immune response is present as is seen in immunotherapy 1,2
-<p><strong>Choline</strong> is a precursor of acetylcholine (ACH), a component of cell membranes which is commonly examined in <a href="/articles/mr-spectroscopy-1">MR spectroscopy</a>. It resonates at 3.2 ppm chemical shift. Infant’s brain shows - for active myelination with synthesis of membrane constituents - high choline signals <sup>3-5</sup>.</p><p>Choline is a marker of cellular membrane turnover and therefore elevated in <a href="/articles/brain-tumours">neoplasms</a>, demyelination, inflammation and gliosis <sup>1</sup>.</p><p>It is useful in a number of scenarios: </p><ul>- +<p><strong>Choline</strong> is a precursor of acetylcholine (ACH), a component of cell membranes which is commonly examined in <a href="/articles/mr-spectroscopy-1">MR spectroscopy</a>. It resonates at 3.2 ppm chemical shift. Infant’s brain shows - for active myelination with synthesis of membrane constituents - high choline signals <sup>3-6</sup>.</p><p>Choline is a marker of cellular membrane turnover and therefore elevated in <a href="/articles/brain-tumours">neoplasms</a>, demyelination, inflammation and gliosis <sup>1</sup>.</p><p>It is useful in a number of scenarios: </p><ul>
References changed:
- 6. Peden C, Cowan F, Bryant D et al. Proton MR Spectroscopy of the Brain in Infants. J Comput Assist Tomogr. 1990;14(6):886-94. <a href="https://doi.org/10.1097/00004728-199011000-00004">doi:10.1097/00004728-199011000-00004</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/2229562">Pubmed</a>
Unable to process the form. Check for errors and try again.