Diffuse cerebellar atrophy
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Diffuse atrophy of the cerebellum refers to a progressive and irreversible reduction in cerebellar volume. It is a relatively common finding and found in a wide variety of clinical scenarios.
Terminology
Diffuse cerebellar atrophy can be difficult to distinguish from global cerebellar hypoplasia on a single study and can only be distinguished from the latter by demonstrating or implying (clinically) that there has been progressive change over time 9.
Pathology
Aetiology
Diffuse atrophy can result from a variety of causes:
- normal ageing
- alcoholic cerebellar degeneration
- drugs, e.g. phenytoin cerebellar degeneration
- chronic temporal lobe epilepsy (independently from phenytoin use) 7
- cerebellitis
- multisystem atrophy (MSA) 4
- superficial siderosis 8
- ataxia telangiectasia
- Friedreich ataxia
- Fahr disease: atrophy not specific to cerebellum
- paraneoplastic cerebellar degeneration (PCD)
- olivopontocerebellar atrophy (OPCA) 6
- cerebrotendinous xanthomatosis
- Marinesco-Sjögrensyndrome (MSS) 5
Differential diagnosis
-<p><strong>Diffuse atrophy of the cerebellum</strong> refers to a progressive and irreversible reduction in cerebellar volume. It is a relatively common finding and found in a wide variety of clinical scenarios. </p><h4>Terminology</h4><p><a href="/articles/diffuse-cerebellar-atrophy">Diffuse cerebellar atrophy</a> can be difficult to distinguish from <a title="Cerebellar hypoplasia" href="/articles/cerebellar-hypoplasia">global cerebellar hypoplasia</a> on a single study and can only be distinguished from the latter by demonstrating or implying (clinically) that there has been progressive change over time <sup>9</sup>. </p><h4>Pathology</h4><h5>Aetiology</h5><p>Diffuse atrophy can result from a variety of causes:</p><ul>- +<p><strong>Diffuse atrophy of the cerebellum</strong> refers to a progressive and irreversible reduction in cerebellar volume. It is a relatively common finding and found in a wide variety of clinical scenarios. </p><h4>Terminology</h4><p><a href="/articles/diffuse-cerebellar-atrophy">Diffuse cerebellar atrophy</a> can be difficult to distinguish from <a href="/articles/cerebellar-hypoplasia">global cerebellar hypoplasia</a> on a single study and can only be distinguished from the latter by demonstrating or implying (clinically) that there has been progressive change over time <sup>9</sup>. </p><h4>Pathology</h4><h5>Aetiology</h5><p>Diffuse atrophy can result from a variety of causes:</p><ul>
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