Diffuse cerebellar atrophy
Updates to Article Attributes
Body
was changed:
Diffuse atrophy of the cerebellum refers to a progressive and irreversible reduction in cerebellar volume. It is a relatively common finding and found in a wide variety of clinical scenarios.
Terminology
Diffuse cerebellar atrophy can be difficult to distinguish from global cerebellar hypoplasia on a single study and can only be distinguished from the latter by demonstrating or implying (clinically) that there has been progressive change over time 9.
Pathology
Aetiology
Diffuse atrophy can result from a variety of causes:
- normal
ageingaging - drugs
- multiple system atrophy 4
- hereditary cerebellar ataxias
- chronic temporal lobe epilepsy (independently from phenytoin use) 7
- cerebellitis
- paraneoplastic cerebellar degeneration
- superficial siderosis 8
- Fahr disease: atrophy not specific to cerebellum
- cerebrotendinous xanthomatosis
- Marinesco-Sjögrensyndrome 5
- JC virus granule cell neuronopathy 10
Differential diagnosis
-<li>normal ageing</li>- +<li>normal aging</li>
-<li><a href="/articles/ataxia-telangiectasia">ataxia telangiectasia</a></li>- +<li><a href="/articles/ataxia-telangiectasia">ataxia-telangiectasia</a></li>
Unable to process the form. Check for errors and try again.