Extrapyramidal system

Last revised by Rohit Sharma on 29 Jun 2024

The extrapyramidal system is the part of the motor system involved in modulation and regulation of movement. As its name suggests, it is distinct from the motor fibres that are relayed through the pyramids of the medulla oblongata (corticospinal and corticobulbar tracts).

Although the extrapyramidal system is not well defined 1, it is generally considered to be composed of nerve cells, nerve tracts and pathways that connect the cerebral cortex, basal ganglia, thalamus, cerebellum, reticular formation, and spinal neurones. Brainstem nuclei of the extrapyramidal system include the red nucleus and substantia nigra.

History and etymology

The term 'extrapyramidal' was introduced by Ukranian physician Johann Prus in 1898 following his observation that even with transection of corticospinal tracts, cortical epileptic activity still resulted in muscle activation 1.

ADVERTISEMENT: Supporters see fewer/no ads

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.