Granulomatosis with polyangiitis (CNS manifestations)
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CNS manifestations of granulomatosis with polyangiitis (GPA) (previously known as Wegener's granulomatosis) are rare. Granulomatosis with polyangiitis (Wegener granulomatosis), is is a multi-system systemic necrotizing non-caseating granulomatous vasculitis affecting small to medium-sized arteries, capillaries and veins.
Epidemiology
CNS manifestations of GPA occur only in ~5% (range 2-9%) of the patients.1,2.
Pathology
GPA manifests in the CNS as:1,2:
- cerebral or meningeal granulomatous lesions
- small vessel CNS vasculitis causing infarcts and arterial occlusion
- intracranial haemorrhage
- continuous invasion of an extracranial granuloma
-<p><strong>CNS manifestations of granulomatosis with polyangiitis </strong>(<strong>GPA</strong>) (previously known as<strong> Wegener's granulomatosis</strong>) are rare. <a href="/articles/granulomatosis-with-polyangiitis">Granulomatosis with polyangiitis (Wegener granulomatosis</a>), is a multi-system systemic necrotizing non-caseating granulomatous vasculitis affecting small to medium-sized arteries, capillaries and veins.</p><h4>Epidemiology</h4><p>CNS manifestations of GPA occur only in ~5% (range 2-9%) of the patients <sup>1,2</sup>.</p><h4>Pathology</h4><p>GPA manifests in the CNS as <sup>1,2</sup>:</p><ul>- +<p><strong>CNS manifestations of granulomatosis with polyangiitis </strong>(<strong>GPA</strong>) (previously known as<strong> Wegener's granulomatosis</strong>) are rare. <a href="/articles/granulomatosis-with-polyangiitis">Granulomatosis with polyangiitis</a> is a multi-system systemic necrotizing non-caseating granulomatous vasculitis affecting small to medium-sized arteries, capillaries and veins.</p><h4>Epidemiology</h4><p>CNS manifestations of GPA occur only in ~5% (range 2-9%) of the patients.<sup>1,2</sup></p><h4>Pathology</h4><p>GPA manifests in the CNS as:<sup>1,2</sup></p><ul>
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