Granulomatosis with polyangiitis (upper respiratory tract manifestations)

Mr Andrew Murphy and Dr Henry Knipe et al.

The upper respiratory tract manifestations of granulomatosis with polyangiitis (GPA) (previously known as Wegener's granulomatosis) are common and affect most patients. . Granulomatosis with polyangiitis (Wegener granulomatosis), is a multi-system systemic necrotizing non-caseating granulomatous vasculitis affecting small to medium-sized arteries, capillaries and veins.

The majority of patients of GPA have upper respiratory tract involvement, most commonly presenting with rhinitis and epistaxis 1,3.

GPA manifests in the upper respiratory tract with 1-3:

  • sinusitis/mastoiditis/otitis
  • sinonasal mucosal ulcers
  • bone deformities, e.g. nasal septal perforation, nasal saddle deformity
  • subglottic stenosis

Possible considerations include:

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Article information

rID: 43203
System: Head & Neck
Section: Pathology
Synonyms or Alternate Spellings:
  • Upper respiratory tract manifestations of Wegener granulomatosis
  • Upper respiratory tract manifestations of granulomatosis with polyangiitis (GPA)

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    Case 3: with sinus and nasal septal involvement
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