Hot cross bun sign (pons)

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The hot cross bun sign refers to the MRI appearance of the pons when T2 hyperintensity forms a cross on axial images, representing selective degeneration of transverse pontocerebellar tracts and median pontine raphe nuclei. It has been described in a variety of neurodegenerative diseases ¹:

multiple system atrophy, cerebellar type (MSA-C) (classic sign)
spinocerebellar ataxia (various types) ⁵
cerebral vasculitis (causing Wallerian degeneration of pontocerebellar tracts) ⁴
variant Creutzfeldt-Jakob disease (vCJD)
JC virus granule cell neuronopathy ³

-The hot cross bun sign refers to the MRI appearance of the <a href="/articles/pons">pons</a> when T2 hyperintensity forms a cross on axial images, representing selective degeneration of pontocerebellar tracts. It has been described in a variety of <a href="/articles/neurodegenerative-disease">neurodegenerative diseases</a> 1:<ul>
~~-<li><a href="/articles/multiple-system-atrophy">multiple system atrophy (MSA)</a></li>~~
+The hot cross bun sign refers to the MRI appearance of the <a href="/articles/pons">pons</a> when T2 hyperintensity forms a cross on axial images, representing selective degeneration of transverse pontocerebellar tracts and median pontine raphe nuclei. It has been described in a variety of <a href="/articles/neurodegenerative-disease">neurodegenerative diseases</a> 1:<ul>
+<li>
+<a href="/articles/multiple-system-atrophy">multiple system atrophy, cerebellar type (MSA-C)</a> (classic sign)</li>

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Hot cross bun sign (pons)

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