Large cell neuroendocrine carcinoma of the lung
Updates to Article Attributes
Large cell neuroendocrine carcinoma (LCNEC) of the lung is classified as a subtype of large cell carcinoma of the lung. It is also classified as a pulmonary neuroendocrine tumour.
Epidemiology
The incidence peaks around the 6sixthth decade 6. There is an increased male predilection 7.
Pathology
LCNECs are poorly differentiated and high-grade neuroendocrine tumours 10. As with other neuroendocrine cells of the lung, LCNECs arise from Kulchitzky cells of the bronchial mucosa 3.
Associations
There is a strong association with smoking.
Radiographic features
HRCT - CT chest
CT features are non-specific.
LCNECs, in general, tend to present as oval-to-round and well-demarcated masses with lobulated margins. Their size typically ranges from 2 to 5 cm. Internal calcification is uncommon (9-21%) 2,4,7. A slight peripheral predilection may be present 5. There can be homogeneous or inhomogeneous enhancement following contrast 1.
Treatment and prognosis
They tend to be aggressive high-grade tumours with a poor prognosis 6. The overall prognosis is thought to be between that of an atypical pulmonary carcinoid and small cell lung cancer (SCLC) 3.
-<p><strong>Large cell neuroendocrine carcinoma (LCNEC) of the lung</strong> is classified as a subtype of <a href="/articles/large-cell-carcinoma-of-the-lung">large cell carcinoma of the lung</a>. It is also classified as a <a href="/articles/pulmonary-neuroendocrine-tumour">pulmonary neuroendocrine tumour</a>.</p><h4>Epidemiology</h4><p>The incidence peaks around the 6<sup>th </sup>decade <sup>6</sup>. There is an increased male predilection <sup>7</sup>.</p><h4>Pathology</h4><p>LCNECs are poorly differentiated and high-grade neuroendocrine tumours <sup>10</sup>. As with other neuroendocrine cells of the lung, LCNECs arise from <a href="/articles/kulchitzky-cells">Kulchitzky cells</a> of the bronchial mucosa <sup>3</sup>.</p><h5>Associations</h5><p>There is a strong association with smoking.</p><h4>Radiographic features</h4><h5>HRCT - CT chest</h5><p>CT features are non-specific.</p><p>LCNECs, in general, tend to present as oval-to-round and well-demarcated masses with lobulated margins. Their size typically ranges from 2 to 5 cm. Internal calcification is uncommon (9-21%) <sup>2,4,7</sup>. A slight peripheral predilection may be present <sup>5</sup>. There can be homogeneous or inhomogeneous enhancement following contrast <sup>1</sup>.</p><h4>Treatment and prognosis</h4><p>They tend to be aggressive high-grade tumours with a poor prognosis <sup>6</sup>. The overall prognosis is thought to be between that of an <a href="/articles/atypical-pulmonary-carcinoid">atypical pulmonary carcinoid</a> and <a href="/articles/small-cell-lung-cancer-1">small cell lung cancer</a> (SCLC) <sup>3</sup>.</p>- +<p><strong>Large cell neuroendocrine carcinoma (LCNEC) of the lung</strong> is classified as a subtype of <a href="/articles/large-cell-carcinoma-of-the-lung">large cell carcinoma of the lung</a>. It is also classified as a <a href="/articles/pulmonary-neuroendocrine-tumour">pulmonary neuroendocrine tumour</a>.</p><h4>Epidemiology</h4><p>The incidence peaks around the sixth<sup> </sup>decade <sup>6</sup>. There is an increased male predilection <sup>7</sup>.</p><h4>Pathology</h4><p>LCNECs are poorly differentiated and high-grade neuroendocrine tumours <sup>10</sup>. As with other neuroendocrine cells of the lung, LCNECs arise from <a href="/articles/kulchitzky-cells">Kulchitzky cells</a> of the bronchial mucosa <sup>3</sup>.</p><h5>Associations</h5><p>There is a strong association with smoking.</p><h4>Radiographic features</h4><h5>HRCT - CT chest</h5><p>CT features are non-specific.</p><p>LCNECs, in general, tend to present as oval-to-round and well-demarcated masses with lobulated margins. Their size typically ranges from 2 to 5 cm. Internal calcification is uncommon (9-21%) <sup>2,4,7</sup>. A slight peripheral predilection may be present <sup>5</sup>. There can be homogeneous or inhomogeneous enhancement following contrast <sup>1</sup>.</p><h4>Treatment and prognosis</h4><p>They tend to be aggressive high-grade tumours with a poor prognosis <sup>6</sup>. The overall prognosis is thought to be between that of an <a href="/articles/atypical-pulmonary-carcinoid">atypical pulmonary carcinoid</a> and <a href="/articles/small-cell-lung-cancer-1">small cell lung cancer</a> (SCLC) <sup>3</sup>.</p>
Sections changed:
Systems changed:
- Oncology
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