Localised gigantism refers to focal enlargement of part of the body, and is always pathological.
In contrast, generalized gigantism refers to increase in stature and is either physiological (i.e. merely very tall) or due to growth hormone excess (e.g pituitary microadenoma).
Broadly localised gigantism can be divided into two forms 1-2:
- static: the region is overgrown but proceeds to grow in proportion to the rest of the body
- progressive: the enlarged region grows faster than the rest of the body
A number of conditions can result in localised gigantism, including:
- neurofibromatosis type 1 (NF1)
- Klippel-Trenaunay-Weber syndrome
- macrodystrophia lipomatosa
- fibrolipomatous hamartoma of the nerve
- proteus syndrome
- 1. Khan RA, Wahab S, Ahmad I et-al. Macrodystrophia lipomatosa: four case reports. Ital J Pediatr. 2010;36 : 69. doi:10.1186/1824-7288-36-69 - Free text at pubmed - Pubmed citation
- 2. Blacksin M, Barnes FJ, Lyons MM. MR diagnosis of macrodystrophia lipomatosa. AJR Am J Roentgenol. 1992;158 (6): 1295-7. AJR Am J Roentgenol (citation) - Pubmed citation