Ovarian vein thrombosis
Updates to Article Attributes
Ovarian vein thrombosis(actually most often thrombophlebitis) occurs most commonly in postpartum patients and can result in pulmonary emboli. A presentation is usually with acute pelvic pain in the postpartum period, then termed puerperal ovarian vein thrombosis or postpartum ovarian vein thrombosis.
Epidemiology
The estimated incidence of postpartum ovarian vein thrombosis is ~1:600-1:2000 deliveries 16.
Risk factors
pregnancy: most common risk factor 17
oral contraceptives
pelvic infection
malignancy
recent surgery
idiopathic: up to 6℅
Clinical presentation
The dominant symptom of clinically significant ovarian vein thrombosis is lower abdominal / right lower quadrant pain and fever, which which usually appears approximately ten days postpartum with no response to antibiotic treatment. There There may occasionally be a palpable mass felt in the right iliac fossa.
Pathology
Location
in ~80-90% of cases, the right ovarian vein is involved, possibly due to retrograde flow in the left vein preventing stasis and ascending infection
~14% of cases can have bilateral involvement
~6% of cases involve the left ovarian vein only
Radiographic features
Ultrasound
May be difficult if there is overlying bowel gas and the ovarian vein may not be identified in every case 14.
tubular/serpiginous hypoechoic structure in the adnexa adjacent to the ovarian artery
if the ovarian vein is identifiable, the absence of Doppler flow can be a diagnostic feature
CT
-
tubular structure with an enhancing wall and low-attenuation thrombus in the expected location of the ovarian vein
-
remember that
the right ovarian vein drains to the inferior vena cava
the left ovarian vein drains to the left renal vein
-
MRI
A filling defect in the ovarian vein will be observed as a loss of the normal flow void on T2 weighted images, with asymmetric enlargement and oedema of the ipsilateral ovary.
Treatment and prognosis
Appropriate treatment consists of a combination of anticoagulation and antibiotics. However, mortality rates of up to 5% have been observed, making the diagnosis an important one to consider in the postpartum patient.
Complications
Differential diagnosis
Considerations include:
acute appendicitis: can be differential for the clinical presentation
-<p><strong>Ovarian vein thrombosis</strong> (actually most often thrombophlebitis) occurs most commonly in postpartum patients and can result in pulmonary emboli. A presentation is usually with acute pelvic pain in the postpartum period, then termed <strong>puerperal ovarian vein thrombosis </strong>or <strong>postpartum ovarian vein thrombosis</strong>.</p><h4>Epidemiology</h4><p>The estimated incidence of postpartum ovarian vein thrombosis is ~1:600-1:2000 deliveries <sup>16</sup>.</p><h5>Risk factors</h5><ul>-<li><p>pregnancy: most common risk factor <sup>17</sup></p></li>-<li><p>oral contraceptives</p></li>-<li><p>pelvic infection</p></li>-<li><p>malignancy</p></li>-<li><p>recent surgery</p></li>-<li><p>idiopathic: up to 6℅</p></li>-</ul><h4>Clinical presentation</h4><p>The dominant symptom of clinically significant ovarian vein thrombosis is lower abdominal / right lower quadrant pain and fever, which usually appears approximately ten days postpartum with no response to antibiotic treatment. There may occasionally be a palpable mass felt in the right iliac fossa.</p><h4>Pathology</h4><h5>Location</h5><ul>-<li><p>in ~80-90% of cases, the right ovarian vein is involved, possibly due to retrograde flow in the left vein preventing stasis and ascending infection</p></li>-<li><p>~14% of cases can have bilateral involvement</p></li>-<li><p>~6% of cases involve the left ovarian vein only</p></li>-</ul><h4>Radiographic features</h4><h5>Ultrasound </h5><p>May be difficult if there is overlying bowel gas and the ovarian vein may not be identified in every case <sup>14</sup>.</p><ul>-<li><p>tubular/serpiginous hypoechoic structure in the adnexa adjacent to the ovarian artery</p></li>-<li><p>if the ovarian vein is identifiable, the absence of Doppler flow can be a diagnostic feature</p></li>-</ul><h5>CT</h5><ul><li>-<p>tubular structure with an enhancing wall and low-attenuation thrombus in the expected location of the ovarian vein</p>-<ul><li>-<p>remember that</p>-<ul>-<li><p>the right <a href="/articles/gonadal-vein">ovarian vein</a> drains to the <a href="/articles/inferior-vena-cava-1">inferior vena cava</a></p></li>-<li><p>the left ovarian vein drains to the left <a href="/articles/renal-vein-1">renal vein</a></p></li>-</ul>-</li></ul>-</li></ul><h5>MRI</h5><p>A filling defect in the ovarian vein will be observed as a loss of the normal flow void on T2 weighted images, with asymmetric enlargement and oedema of the ipsilateral ovary.</p><h4>Treatment and prognosis</h4><p>Appropriate treatment consists of a combination of anticoagulation and antibiotics. However, mortality rates of up to 5% have been observed, making the diagnosis an important one to consider in the postpartum patient.</p><h5>Complications</h5><ul><li><p><a href="/articles/pulmonary-embolism">pulmonary emboli</a> <sup>15</sup></p></li></ul><h4>Differential diagnosis</h4><p>Considerations include:</p><ul>-<li><p><a href="/articles/hydroureter-1">hydroureter</a></p></li>-<li><p><a href="/articles/acute-appendicitis-2">acute appendicitis</a>: can be differential for the clinical presentation</p></li>- +<p><strong>Ovarian vein thrombosis</strong> (actually most often thrombophlebitis) occurs most commonly in postpartum patients and can result in pulmonary emboli. A presentation is usually with acute pelvic pain in the postpartum period, then termed <strong>puerperal ovarian vein thrombosis </strong>or <strong>postpartum ovarian vein thrombosis</strong>.</p><h4>Epidemiology</h4><p>The estimated incidence of postpartum ovarian vein thrombosis is ~1:600-1:2000 deliveries <sup>16</sup>.</p><h5>Risk factors</h5><ul>
- +<li><p>pregnancy: most common risk factor <sup>17</sup></p></li>
- +<li><p>oral contraceptives</p></li>
- +<li><p>pelvic infection</p></li>
- +<li><p>malignancy</p></li>
- +<li><p>recent surgery</p></li>
- +<li><p>idiopathic: up to 6℅</p></li>
- +</ul><h4>Clinical presentation</h4><p>The dominant symptom of clinically significant ovarian vein thrombosis is lower abdominal / right lower quadrant pain and fever, which usually appears approximately ten days postpartum with no response to antibiotic treatment. There may occasionally be a palpable mass felt in the right iliac fossa.</p><h4>Pathology</h4><h5>Location</h5><ul>
- +<li><p>in ~80-90% of cases, the right ovarian vein is involved, possibly due to retrograde flow in the left vein preventing stasis and ascending infection</p></li>
- +<li><p>~14% of cases can have bilateral involvement</p></li>
- +<li><p>~6% of cases involve the left ovarian vein only</p></li>
- +</ul><h4>Radiographic features</h4><h5>Ultrasound </h5><p>May be difficult if there is overlying bowel gas and the ovarian vein may not be identified in every case <sup>14</sup>.</p><ul>
- +<li><p>tubular/serpiginous hypoechoic structure in the adnexa adjacent to the ovarian artery</p></li>
- +<li><p>if the ovarian vein is identifiable, the absence of Doppler flow can be a diagnostic feature</p></li>
- +</ul><h5>CT</h5><ul><li>
- +<p>tubular structure with an enhancing wall and low-attenuation thrombus in the expected location of the ovarian vein</p>
- +<ul><li>
- +<p>remember that</p>
- +<ul>
- +<li><p>the right <a href="/articles/gonadal-vein">ovarian vein</a> drains to the <a href="/articles/inferior-vena-cava-1">inferior vena cava</a></p></li>
- +<li><p>the left ovarian vein drains to the left <a href="/articles/renal-vein-1">renal vein</a></p></li>
- +</ul>
- +</li></ul>
- +</li></ul><h5>MRI</h5><p>A filling defect in the ovarian vein will be observed as a loss of the normal flow void on T2 weighted images, with asymmetric enlargement and oedema of the ipsilateral ovary.</p><h4>Treatment and prognosis</h4><p>Appropriate treatment consists of a combination of anticoagulation and antibiotics. However, mortality rates of up to 5% have been observed, making the diagnosis an important one to consider in the postpartum patient.</p><h5>Complications</h5><ul><li><p><a href="/articles/pulmonary-embolism">pulmonary emboli</a> <sup>15</sup></p></li></ul><h4>Differential diagnosis</h4><p>Considerations include:</p><ul>
- +<li><p><a href="/articles/hydroureter-1">hydroureter</a></p></li>
- +<li><p><a href="/articles/acute-appendicitis-2">acute appendicitis</a>: can be differential for the clinical presentation</p></li>
References changed:
- 13. Hadas-Halpern I, Patlas M, Fisher D. Postpartum Ovarian Vein Thrombophlebitis: Sonographic Diagnosis. Abdom Imaging. 2002;27(1):93-5. <a href="https://doi.org/10.1007/s00261-001-0034-7">doi:10.1007/s00261-001-0034-7</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/11740617">Pubmed</a>
- 13. Hadas-halpern I, Patlas M, Fisher D. Postpartum ovarian vein thrombophlebitis: sonographic diagnosis. Abdom Imaging. 27 (1): 93-5. - <a href="http://www.ncbi.nlm.nih.gov/pubmed/11740617">Pubmed citation</a><div class="ref_v2"></div>
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