Pituitary region masses with intrinsic high T1 signal, also referred to as suprasellar hotspots, are relatively frequently encountered, and the presence of high T1 signal narrows the differential somewhat.
Differential diagnosis
The differential can be divided by the substance causing the T1 hyperintensity 2:
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blood
hemorrhagic pituitary macroadenoma (with or without clinical pituitary apoplexy) (most common 3)
thrombosed aneurysm
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fat
postoperative fat packing
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protein
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calcification
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normal variant
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posterior pituitary bright spot
normal posterior pituitary
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normal anterior pituitary 1
pregnancy
first 3 months of life
total parenteral nutrition (TPN)
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