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Proptosis (rare plural: proptoses) refers to forward protrusion of the globe with respect to the orbit. Proptosis can be relative (to the contralateral eye), comparative (to a prior measurement of the same eye), or absolute (based on normal population reference values).
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Exophthalmos also describes forward protrusion of the globe. Several authors use the terms differently, which can be confusing:
- proptosis and exophthalmos are often used interchangeably
- exophthalmos used to refer to severe (>18 mm) proptosis 5
- exophthalmos used to refer to endocrine-related proptosis 6
Proptosis can also be used for other viscera (although rarely seen in contemporaneous usage), but exophthalmos only for the eyes.
Enophthalmos is the antonym, referring to displacement of the globe posteriorly.
The causes of proptosis are broad and include a wide range of mass lesions that originate within the cranium, sinuses, paranasal spaces, and orbit 3:
- thyroid orbitopathy (the most common cause of uni/bilateral proptosis in adults)
- lymphoma, e.g. orbital lymphoma
- meningioma, e.g. sphenoid wing meningioma
- orbital metastasis
- trauma, e.g. iatrogenic, postsurgical
- vascular lesions
- orbital inflammatory syndrome (also known as orbital pseudotumor)
Assessment of proptosis on cross-sectional imaging is difficult and dependant on the study being acquired in the correct plane:
- the plane of the study must be parallel to the head of the optic nerve and the lens
- the patient must have their eyes open and be looking forward with no eye movement
The reference line for measurement of proptosis is the interzygomatic line (a line is drawn at the anterior portions of the zygomatic bones):
- the upper limit of normal distance from this line to the anterior surface of the globe is 23 mm, above which indicates proptosis 4
- the lower limit of normal distance from this line to the posterior surface of the globe is 5.9 mm, below which indicates proptosis 2
The thickness of the extraocular muscles can also be used 1.
MRI may also be used in evaluation due to its multiplanar and inherent contrast capabilities. Use of MRI prevents ionizing radiation of the orbits and risk of radiation-induced cataracts. The imaging findings are similar to those described above for CT.
- 1. Szucs-Farkas Z, Toth J, Balazs E et-al. Using morphologic parameters of extraocular muscles for diagnosis and follow-up of Graves' ophthalmopathy: diameters, areas, or volumes?. AJR Am J Roentgenol. 2002;179 (4): 1005-10. doi:10.2214/ajr.179.4.1791005 - Pubmed citation
- 2. Ozgen A & Ariyurek M. Normative Measurements of Orbital Structures Using CT. AJR Am J Roentgenol. 1998;170(4):1093-6. doi:10.2214/ajr.170.4.9530066 - Pubmed
- 3. Lloyd GA. The radiological investigation of proptosis. Br J Radiol. 1970;43 (505): 1-18. Br J Radiol (citation) - doi:10.1259/0007-1285-43-505-1 - Pubmed citation
- 4. Haaga JR, Boll D. CT and MRI of the whole body. Mosby. (2009) ISBN:0323053750. Read it at Google Books - Find it at Amazon
- 5. Epstein O, Cookson J, Perkin GD et-al. Clinical Examination 3e. Mosby. (2003) ISBN:0723432295. Read it at Google Books - Find it at Amazon
- 6. Garrity JA, Henderson JW. Henderson's Orbital Tumors, 4e. Lippincott Williams & Wilkins. (2007) ISBN:0781738695. Read it at Google Books - Find it at Amazon