Regional migratory osteoporosis

Last revised by Henry Knipe on 25 Jan 2022

Regional migratory osteoporosis is a rare arthralgia affecting the weight-bearing joints of the lower limb. 

Regional migratory osteoporosis is most common in middle-aged men 1.

The classic clinical presentation is a history of non-traumatic joint pain, which peaks at 2 months and then resolves, with the subsequent presentation of pain in another joint between 2-11 years later 1,2. They can also present with an insufficiency fracture

The etiology is unclear 1,3 with the relationship to transient osteoporosis of the hipbone marrow edema syndrome and osteonecrosis debated 2. Joint involvement is variable although most commonly is proximal-to-distal; more than one joint can be involved at once and intra-articular migration (e.g. one femoral condyle then another) can also occur 1

Bone marrow edema with subchondral sparing and no subchondral fracture 1.

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