Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Knipe H, Traditional serrated adenoma. Reference article, Radiopaedia.org (Accessed on 02 May 2024) https://doi.org/10.53347/rID-153787
Traditional serrated adenomas are a type of premalignant serrated colonic polyp.
Epidemiology
They are thought to account for <1% of all colonic polyps and 1-7% of all serrated lesions. They tend to occur in older patients (usually over 50 years) with no significant gender predilection.
Pathology
Many tend to be small (< 10 mm in size) and can be subclassified into BRAF and KRAS subtypes.
Location
They are found predominantly in the distal (left) colon with only rare occurrences in the proximal colon.
History and etymology
They were initially described by T A Longacre et al. in 1990 2.
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1. McCarthy A, Serra S, Chetty R. Traditional Serrated Adenoma: An Overview of Pathology and Emphasis on Molecular Pathogenesis. BMJ Open Gastroenterol. 2019;6(1):e000317. doi:10.1136/bmjgast-2019-000317 - Pubmed
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2. Tanaka Y, Eizuka M, Uesugi N et al. Traditional Serrated Adenoma Has Two Distinct Genetic Pathways for Molecular Tumorigenesis with Potential Neoplastic Progression. J Gastroenterol. 2020;55(9):846-57. doi:10.1007/s00535-020-01697-5 - Pubmed
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3. Bateman A. The Spectrum of Serrated Colorectal Lesions-New Entities and Unanswered Questions. Histopathology. 2021;78(6):780-90. doi:10.1111/his.14305 - Pubmed
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