Waterhouse-Friderichsen syndrome

Changed by Yuranga Weerakkody, 24 Nov 2015

Updates to Article Attributes

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Waterhouse-Friderichsen syndrome (WFS) is one of the causes of non-traumatic adrenal haemorrhage.

Pathology

WFS is due to septicaemia. Common infective agents include 5:

  • meningococcus : traditionally described cause
  • Haemophilus influenzae
  • Pseudomonas aeruginosa
  • Escherichia coli
  • Streptococcus pneumoniae

Radiographic features

Imaging features are often that of non-traumatic adrenal haemorrhage. The correct clinical context is vital in image interpretation.

History and etymology

NamedIt is named after Rupert Waterhouse, English physician (1873-1958), and Carl Friderichsen, Danish paediatrician (1886-1979) 2.

  • -<p><strong>Waterhouse-Friderichsen syndrome (WFS)</strong> is one of the causes of non-traumatic <a href="/articles/adrenal-haemorrhage">adrenal haemorrhage</a>. </p><h4>Pathology</h4><p>WFS is due to septicaemia. Common infective agents include <sup>5</sup>:</p><ul>
  • -<li>meningococcus</li>
  • +<p><strong>Waterhouse-Friderichsen syndrome (WFS)</strong> is one of the causes of non-traumatic <a href="/articles/adrenal-haemorrhage">adrenal haemorrhage</a>.</p><h4>Pathology</h4><p>WFS is due to septicaemia. Common infective agents include <sup>5</sup>:</p><ul>
  • +<li>meningococcus : traditionally described cause</li>
  • -</ul><h4>Radiographic features</h4><p>Imaging features are often that of non-traumatic <a href="/articles/adrenal-haemorrhage">adrenal haemorrhage</a>. The correct clinical context is vital in image interpretation.</p><h4>History and etymology</h4><p>Named after <strong>Rupert Waterhouse</strong>, English physician (1873-1958), and <strong>Carl Friderichsen</strong>, Danish paediatrician (1886-1979) <sup>2</sup>.</p>
  • +</ul><h4>Radiographic features</h4><p>Imaging features are often that of non-traumatic <a href="/articles/adrenal-haemorrhage">adrenal haemorrhage</a>. The correct clinical context is vital in image interpretation.</p><h4>History and etymology</h4><p>It is named after <strong>Rupert Waterhouse</strong>, English physician (1873-1958), and <strong>Carl Friderichsen</strong>, Danish paediatrician (1886-1979) <sup>2</sup>.</p>

References changed:

  • 6. Saad AF, Ford KL, Deprisco G et-al. Adrenomegaly and septic adrenal hemorrhage (Waterhouse-Friderichsen syndrome) in the setting of congenital adrenal hyperplasia. Proc (Bayl Univ Med Cent). 2013;26 (3): 268-9. <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684293">Free text at pubmed</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/23814386">Pubmed citation</a><span class="auto"></span>
  • 7. Kawashima A, Sandler CM, Ernst RD et-al. Imaging of nontraumatic hemorrhage of the adrenal gland. Radiographics. 1999;19 (4): 949-63. <a href="http://dx.doi.org/10.1148/radiographics.19.4.g99jl13949">doi:10.1148/radiographics.19.4.g99jl13949</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/10464802">Pubmed citation</a><span class="auto"></span>

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