Acute leukoencephalopathy with restricted diffusion (ALERD)

Case contributed by Utkarsh Kabra
Diagnosis almost certain

Presentation

Fever with seizures

Patient Data

Age: 4 months
Gender: Female

The study reveals extensive diffusion restriction involving bilateral internal capsules, bilateral periventricular, deep, and subcortical white matter with sparing of the cortex. T2/FLAIR hyperintensities are seen in basal ganglia with no diffusion restriction.

Case Discussion

The imaging pattern on diffusion-weighted images is called the 'bright tree' appearance, and the findings are pathognomonic for acute leukoencephalopathy with restricted diffusion (ALERD).

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