Cerebral amyloid angiopathy-related inflammation (CAA-RI)

Case contributed by Yves Leonard Voss
Diagnosis probable


Progressive cognitive impairment, apraxia, and aphasia for a few weeks.

Patient Data

Age: 70 years
Gender: Female

Left occipital cortical and subcortical FLAIR hyperintensity and grouped microbleeds. Very subtle leptomeningeal enhancement. No restricted diffusion. 

A few other microbleeds are found in the left temporal lobe. 

Case Discussion

Clinical history of progressive cognitive decline over a few weeks and asymmetrically grouped cerebral microbleeds with focal corticosubcortical FLAIR hyperintensity, untypical for stroke and without restricted diffusion, we suspected cerebral amyloid angiopathy related inflammation (CAA-RI). 

Probatory corticoid treatment resolved FLAIR changes and the patient returned to near normal cognitive function. 

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