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There is no normal endometirum within these images.
Most of the specimen is composed of endometrial tissue displaying tightly packed, back-to-back, complex glands with scant intervening stroma that contains occasional clusters of foamy histiocytes. Cells lining these glands show mild cytological atypia with nuclear stratification, mildly enlarged hyperchromatic nuclei and scattered mitotic figures.
A smaller component of the specimen, however, is composed of solid sheets and occasional glands within a desmoplastic stroma, showing prominent necrosis and apoptotic debris. Tumour cells in these areas are display marked cytological atypia, with large vesicular, pleomorphic nuclei, prominent nucleoli, scant cytoplasm and abundant mitotic figures. There is focal necrosis.
Immunohistochemistry was performed on a section containing poorly differentiated areas with the following results:
- Broad spectrum cytokeratin AE1/AE3: Positive
- ER and PR: Negative
- CK5: Focal, weak
- P53: Weak, patchy
- Chromogranin and Synaptophysin: Negative