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Periventricular leukomalacia

Case contributed by Ammar Haouimi
Diagnosis almost certain

Presentation

Developmental delay. History of a perinatal insult.

Patient Data

Age: 2 years
Gender: Male
mri

The MRI sequences demonstrate:

  • irregular margins of the bodies and trigones of the lateral ventricles with ventriculomegaly

  • loss of periventricular white matter with increased FLAIR and T2 signal (gliosis)

  • thinning of the corpus callosum mainly at the isthmus

Case Discussion

The clinical history and the MR findings are most consistent with end-stage periventricular leukomalacia (PVL).

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