Presentation
MRI following initial normal CT Head. Presenting with worsening personality changes, memory impairment, movement disorder and ataxia. ?demyelination.
Patient Data
Age: 45 years
Gender: Female
From the case:
Sporadic Creutzfeld-Jakob disease
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Symmetrical cortical grey-matter and striatal hyperintensity on DWI, with abnormal restricted diffusion.
Case Discussion
T2/FLAIR or DWI sequences demonstrate hyperintensity of the cortical grey matter and striatum. Relative sparing of the occipital lobes and cerebellum.
In combination with the clinical picture and CSF 14-3-3 protein isolation, a diagnosis of sporadic CJD was made.
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