2-hydroxyglutarate
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2-hydroxyglutarate is a metabolite that accumulates in the brains of patients with IDH-1 mutated (IDH-1 positive) brain tumours, particularly diffuse low-grade gliomas. Although not in widespread clinical use, it is likely that 2-hydroxyglutarate, which resonates at 2.25 ppm, will be able to be detected in vivo using MR spectroscopy, and thus IDH-1 status could be detected preoperatively 1. This is important, as it is increasingly recognised that IDH-1 status has a significant impact on prognosis. Unfortunately, as it is a small peak, nestled among the GABA and glutamate/glutamine peaks (which overlap as it is), it requires more advanced MRS and post-processing techniques than are currently routinely available.
-<p><strong>2-hydroxyglutarate</strong> is a metabolite that accumulates in the brains of patients with <a href="/articles/isocitrate-dehydrogenase-idh">IDH-1</a> mutated (IDH-1 positive) brain tumours, particularly <a href="/articles/diffuse-astrocytoma-1">diffuse low-grade gliomas</a>. Although not in widespread clinical use, it is likely that 2-hydroxyglutarate, which resonates at 2.25 ppm, will be able to be detected in vivo using <a href="/articles/mr-spectroscopy-1">MR spectroscopy</a>, and thus IDH-1 status could be detected preoperatively <sup>1</sup>. This is important, as it is increasingly recognised that IDH-1 status has a significant impact on prognosis. Unfortunately, as it is a small peak, nestled among the <a href="/articles/gamma-aminobutyric-acid-gaba-peak">GABA</a> and <a href="/articles/glutamine-glutamate-peak">glutamate/glutamine peaks</a> (which overlap as it is), it requires more advanced MRS and post-processing techniques than are currently routinely available.</p>- +<p><strong>2-hydroxyglutarate</strong> is a metabolite that accumulates in the brains of patients with <a href="/articles/isocitrate-dehydrogenase">IDH-1</a> mutated (IDH-1 positive) brain tumours, particularly <a href="/articles/diffuse-astrocytoma-1">diffuse low-grade gliomas</a>. Although not in widespread clinical use, it is likely that 2-hydroxyglutarate, which resonates at 2.25 ppm, will be able to be detected in vivo using <a href="/articles/mr-spectroscopy-1">MR spectroscopy</a>, and thus IDH-1 status could be detected preoperatively <sup>1</sup>. This is important, as it is increasingly recognised that IDH-1 status has a significant impact on prognosis. Unfortunately, as it is a small peak, nestled among the <a href="/articles/gamma-aminobutyric-acid-gaba-peak">GABA</a> and <a href="/articles/glutamine-glutamate-peak">glutamate/glutamine peaks</a> (which overlap as it is), it requires more advanced MRS and post-processing techniques than are currently routinely available.</p>
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