Serum CA-125 is well recognised as an ovarian cancer-associated marker and is an antigen determinant on a high-molecular-weight glycoprotein. The normal range of CA-125 is 0-35 U/mL.

Serum CA-125 levels can also be used to monitor the response to treatment as well as a prognostic indicator since the risk of disease mortality is higher in patients with a higher serum level of the marker.

It may be elevated for a number of malignant and benign reasons 9:

Malignant conditions

Benign conditions

See other tumour markers here.

Share article

Article information

rID: 14477
Sections: Pathology, Gamuts
Synonyms or Alternate Spellings:
  • Causes of CA-125 elevation
  • Serum CA 125 elevation
  • Elevation of CA-125 level
  • CA 125 elevation

Support Radiopaedia and see fewer ads

Cases and figures

  • Drag
    Case 1: tuberculosis peritonitis
    Drag here to reorder.
  • Drag
    Case 2: ovarian malignancy
    Drag here to reorder.
  • Updating… Please wait.

    Alert accept

    Error Unable to process the form. Check for errors and try again.

    Alert accept Thank you for updating your details.