Müller-Weiss syndrome

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Brailsford disease
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Mueller Weiss syndrome(also known as Brailsford disease 3) refers to spontaneous multifactorial adult onset osteonecrosis of the tarsal navicular. This syndrome is distinct from Köhler disease, the osteonecrosis of the tarsal navicular bone that occurs in children.

Epidemiology

It occurs in adults between 40 and 60 years of age and is more common in females. Patients present with mid- and hindfoothind foot pain and pes planovarus.

Radiographic features

Plain radiograph

Plain radiographic features can include

  • comma-shaped deformity due to collapse of the lateral part of the bone
  • medial or dorsal protrusion of a portion of the bone or the entire navicular bone

The disease may be bilateral or asymmetric and associated with pathologic fractures.

There is a radiographic staging.

MRI
  • can show oedema on STIR / PD FS images and is more sensitive in picking up the early changes due to its ability to detect marrow signal changes

Treatment and prognosis

The disease can be progressive at times, and it is associated with severe pain and disability. Initially, it is treated conservatively with analgesics and orthotics which if they fail then surgical treatment is considered.

History and etymology

Schmidt reported the first case in 1925. However W Muller was the first to propose that the was due to an abnormal compressive force upon the ankle or a congenital abnormality. K Weiss concluded that the appearances on plain film were analogous to those seen with Kienbock disease, i.e. an osteonecrotic aetiology.

  • -<p><strong>Mueller Weiss syndrome</strong> refers to spontaneous multifactorial adult onset osteonecrosis of the tarsal navicular. This syndrome is distinct from <a href="/articles/k-hler-disease">K</a><a href="/articles/k-hler-disease">öhler disease</a>, the osteonecrosis of the tarsal navicular bone that occurs in children.</p><h4>Epidemiology</h4><p>It occurs in adults between 40 and 60 years of age and is more common in females. Patients present with mid- and hindfoot pain and pes planovarus.</p><h4>Radiographic features</h4><h5>Plain radiograph</h5><p>Plain radiographic features can include</p><ul>
  • +<p><strong>Mueller Weiss syndrome </strong>(also known as <strong>Brailsford disease </strong><sup>3</sup>) refers to spontaneous multifactorial adult onset osteonecrosis of the tarsal navicular. This syndrome is distinct from <a href="/articles/k-hler-disease">K</a><a href="/articles/k-hler-disease">öhler disease</a>, the osteonecrosis of the tarsal navicular bone that occurs in children.</p><h4>Epidemiology</h4><p>It occurs in adults between 40 and 60 years of age and is more common in females. Patients present with mid- and hind foot pain and pes planovarus.</p><h4>Radiographic features</h4><h5>Plain radiograph</h5><p>Plain radiographic features can include</p><ul>
  • -</ul><p>The disease may be bilateral or asymmetric and associated with pathologic fractures.</p><p>There is a radiographic <a href="/articles/staging">staging</a>.</p><h5>MRI</h5><ul><li>can show oedema on STIR / PD FS images and is more sensitive in picking up the early changes due to its ability to detect marrow signal changes</li></ul><h4>Treatment and prognosis</h4><p>The disease can be progressive at times, and it is associated with severe pain and disability. Initially, it is treated conservatively with analgesics and orthotics which if they fail then surgical treatment is considered.</p>
  • +</ul><p>The disease may be bilateral or asymmetric and associated with pathologic fractures.</p><p>There is a radiographic <a href="/articles/staging">staging</a>.</p><h5>MRI</h5><ul><li>can show oedema on STIR / PD FS images and is more sensitive in picking up the early changes due to its ability to detect marrow signal changes</li></ul><h4>Treatment and prognosis</h4><p>The disease can be progressive at times, and it is associated with severe pain and disability. Initially, it is treated conservatively with analgesics and orthotics which if they fail then surgical treatment is considered.</p><h4>History and etymology</h4><p><strong>Schmidt </strong>reported the first case in 1925. However <strong>W Muller</strong> was the first to propose that the was due to an abnormal compressive force upon the ankle or a congenital abnormality. <strong>K Weiss</strong> concluded that the appearances on plain film were analogous to those seen with <a title="Kienbock disease" href="/articles/kienbock-disease-2">Kienbock disease</a>, i.e. an osteonecrotic aetiology.</p>

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