Paraquat-induced lung disease
Updates to Article Attributes
Paraquat-induced lung disease is a potential consequence of ingestion of the non-selective herbicidal agent paraquat (a.k.a.(also known as N,N′-dimethyl-4,4′-bipyridinium dichloride).
Radiographic features
General features
A temporal progression from ground glass opacities, through air space consolidation, and finally to fibrosis.
CT - HRCT Chest
Changes usually begin with ground-glass opacities, which can then lead to consolidation with bronchiectasis or irregular lines 2.
Some patients may also develop a pneumomediastinum +/- pneumothorax 4.
Focal honeycombing can occur after a few weeks. In patients who survive longer, later imaging (i.e. months) may show areas of localised fibrosis containing small cysts 4.
Treatment and prognosis
Once there is lung disease, the condition is thought to carry a very poor prognosis, with the majority inexorably progressing to end-stage respiratory failure 1-3.
See also
-<p><strong>Paraquat-induced lung disease</strong> is a potential consequence of ingestion of the non-selective herbicidal agent paraquat (a.k.a. N,N′-dimethyl-4,4′-bipyridinium dichloride).</p><h4>Radiographic features</h4><h5>General features</h5><p>A temporal progression from <a title="Ground glass opacities (GGO)" href="/articles/ground-glass-opacification-1">ground glass opacities</a>, through <a title="Air space consolidation" href="/articles/air-space-opacification-1">air space consolidation</a>, and finally to <a title="Fibrosis of lung" href="/articles/pulmonary-fibrosis">fibrosis</a>.</p><h5>CT - HRCT Chest</h5><p>Changes usually begin with ground-glass opacities, which can then lead to consolidation with <a title="Bronchiectasis" href="/articles/bronchiectasis">bronchiectasis</a> or irregular lines <sup>2</sup>.</p><p>Some patients may also develop a <a title="Pneumomediastinum" href="/articles/pneumomediastinum">pneumomediastinum</a> +/- <a title="Pneumothorax" href="/articles/pneumothorax">pneumothorax</a> <sup>4</sup>.</p><p>Focal honeycombing can occur after a few weeks. In patients who survive longer, later imaging (i.e. months) may show areas of localised fibrosis containing small cysts <sup>4</sup>.</p><h4>Treatment and prognosis</h4><p>Once there is lung disease, the condition is thought to carry a very poor prognosis, with the majority inexorably progressing to <a title="Respiratory failure" href="/articles/respiratory-failure">end-stage respiratory failure</a> <sup>1-3</sup>.</p><h4>See also</h4><ul><li><a href="/articles/drug-induced-lung-disease-1">drug-induced lung disease</a></li></ul>- +<p><strong>Paraquat-induced lung disease</strong> is a potential consequence of ingestion of the non-selective herbicidal agent paraquat (also known as N,N′-dimethyl-4,4′-bipyridinium dichloride).</p><h4>Radiographic features</h4><h5>General features</h5><p>A temporal progression from <a href="/articles/ground-glass-opacification-3">ground glass opacities</a>, through <a href="/articles/air-space-opacification-1">air space consolidation</a>, and finally to <a href="/articles/pulmonary-fibrosis">fibrosis</a>.</p><h5>CT Chest</h5><p>Changes usually begin with ground-glass opacities, which can then lead to consolidation with <a href="/articles/bronchiectasis">bronchiectasis</a> or irregular lines <sup>2</sup>.</p><p>Some patients may also develop a <a href="/articles/pneumomediastinum">pneumomediastinum</a> +/- <a href="/articles/pneumothorax">pneumothorax</a> <sup>4</sup>.</p><p>Focal honeycombing can occur after a few weeks. In patients who survive longer, later imaging (i.e. months) may show areas of localised fibrosis containing small cysts <sup>4</sup>.</p><h4>Treatment and prognosis</h4><p>Once there is lung disease, the condition is thought to carry a very poor prognosis, with the majority inexorably progressing to <a href="/articles/respiratory-failure">end-stage respiratory failure</a> <sup>1-3</sup>.</p><h4>See also</h4><ul><li><a href="/articles/drug-induced-lung-disease-1">drug-induced lung disease</a></li></ul>
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