Peripheral nerve sheath tumor

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Peripheral nerve sheath tumours (PNST's) are a group of primary tumours that arise from nerve sheaths.

Pathology

They can be benign or malignant.

Classification

They mat be classified as follows

benign
- schwannoma (peripheral nerve sheath schwannoma)
- neurofibroma (peripheral nerve sheath neurofibroma)
  - localised neurofibroma (~90%)
  - diffuse neurofibroma
  - plexiform neurofibroma: arborising tumour of peripheral nerves that is pathognomonic of NF1
malignant
- malignant peripheral nerve sheath tumour (MPSNT)

Associations

neurofibromatosis type 1 (neurofibromas)

Radiographic features

Imaging, in most cases, cannot reliably distinguish between these tumours.

MRI

As a group they demonstrate the following features

fusiform-shaped mass with tapered ends
a “split-fat” sign
atrophy of the muscles supplied by the involved nerve
a “fascicular sign”
a “target sign”

-<p><strong>Peripheral nerve sheath tumours (PNST's)</strong> are a group of tumours that arise from nerve sheaths.</p><h4>Pathology</h4><p>They can be benign or malignant.</p><h5>Classification</h5><p>They mat be classified as follows</p><ul>
+<p><strong>Peripheral nerve sheath tumours (PNST's)</strong> are a group of primary tumours that arise from nerve sheaths.</p><h4>Pathology</h4><p>They can be benign or malignant.</p><h5>Classification</h5><p>They mat be classified as follows</p><ul>
~~-<li><a href="/articles/plexiform-neurofibroma">plexiform neurofibroma</a></li>~~
+<li>
+<a href="/articles/plexiform-neurofibroma">plexiform neurofibroma</a>: arborising tumour of peripheral nerves that is pathognomonic of NF1</li>
-</ul><h5>Associations</h5><ul><li><a href="/articles/neurofibromatosis-type-1">neurofibromatosis type 1</a></li></ul><h4>Radiographic features</h4><h5>MRI</h5><p>As a group they demonstrate the following features</p><ul>
+</ul><h5>Associations</h5><ul><li>
+<a href="/articles/neurofibromatosis-type-1">neurofibromatosis type 1</a> (neurofibromas)</li></ul><h4>Radiographic features</h4><p>Imaging, in most cases, cannot reliably distinguish between these tumours.</p><h5>MRI</h5><p>As a group they demonstrate the following features</p><ul>

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