Raised intracranial pressure

Changed by Daniel J Bell, 8 Oct 2018
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Raised intracranial pressure is a pathological increase in the intracranial pressure in the cranium and is a medical emergency. 

Clinical presentation

The symptoms and signs of raised intracranial pressure are often non-specific and insidious in onset:

  • headache
  • drowsiness
  • anorexia
  • visual disturbances
    • blurred vision: often the first manifestation noted by patients
    • visual field loss: early finding
    • visual acuity is usually preserved
    • double vision
    • "greying out of vision" a.k.a. transient visual obscurations
      • commonly occur with changes in posture
    • papilloedema
  • neck/back pain
  • nausea and/or vomiting
  • convulsions
  • pulsatile tinnitus
  • blackouts
  • decreased GCS/coma

Pathology

Aetiology

Radiographic features

It follows from the Monro-Kellie doctrine that as the CSF pressure inside the skull increases, the brain and blood volume have to accommodate this, resulting in the phenomenon of mass-effect, explaining the findings of raised intracranial pressure on cross-sectional brain imaging:

  • effacement of the ventricles, basal cisterns and other CSF spaces
  • brain herniation
  • loss of grey-white matter differentiation

Treatment and complications

Specific treatment relates to the underlying aetiology.

Complications
  • permanent loss of vision
  • permanent loss of neurological functions
  • death
  • -<p><strong>Raised intracranial pressure</strong> is a pathological increase in the pressure in the cranium and is a medical emergency. </p><p> </p><h4>Pathology</h4><h5>Aetiology</h5><ul>
  • +<p><strong>Raised intracranial pressure</strong> is a pathological increase in the <a href="/articles/intracranial-pressure">intracranial pressure</a> and is a medical emergency. </p><h4>Clinical presentation</h4><p>The symptoms and signs of raised intracranial pressure are often <a href="/articles/non-specific">non-specific</a> and insidious in onset:</p><ul>
  • +<li>headache</li>
  • +<li>drowsiness</li>
  • +<li>anorexia</li>
  • +<li>visual disturbances<ul>
  • +<li>blurred vision: often the first manifestation noted by patients</li>
  • +<li>visual field loss: early finding</li>
  • +<li>visual acuity is usually preserved</li>
  • +<li><a href="/articles/diplopia">double vision</a></li>
  • +<li>"greying out of vision" a.k.a. transient visual obscurations<ul><li>commonly occur with changes in posture</li></ul>
  • +</li>
  • +<li><a href="/articles/papilloedema">papilloedema</a></li>
  • +</ul>
  • +</li>
  • +<li>neck/back pain</li>
  • +<li><a href="/articles/investigating-nausea-and-vomiting-summary">nausea and/or vomiting</a></li>
  • +<li>convulsions</li>
  • +<li><a href="/articles/pulsatile-tinnitus">pulsatile tinnitus</a></li>
  • +<li>blackouts</li>
  • +<li>decreased <a href="/articles/glasgow-coma-scale-1">GCS</a>/coma</li>
  • +</ul><h4>Pathology</h4><h5>Aetiology</h5><ul>
  • +<li>empyema (<a href="/articles/epidural-empyema">epidural</a>/<a href="/articles/subdural-empyema">subdural</a>)</li>
  • -<li>neoplasms</li>
  • +<li>neoplasms<ul>
  • +<li>primary</li>
  • +<li>metastases</li>
  • +</ul>
  • +</li>
  • -<li>extradural</li>
  • -<li>subdural</li>
  • -<li>intracerebral</li>
  • -<li>intraventricular</li>
  • -<li> </li>
  • +<li><a href="/articles/extradural-haemorrhage">extradural</a></li>
  • +<li><a href="/articles/subdural-haemorrhage">subdural</a></li>
  • +<li><a href="/articles/subarachnoid-haemorrhage">subarachnoid</a></li>
  • +<li><a href="/articles/intracerebral-haemorrhage">intracerebral</a></li>
  • +<li><a href="/articles/intraventricular-haemorrhage">intraventricular</a></li>
  • +</ul><h4>Radiographic features</h4><p>It follows from the <a href="/articles/monro-kellie-hypothesis">Monro-Kellie doctrine</a> that as the CSF pressure inside the skull increases, the brain and blood volume have to accommodate this, resulting in the phenomenon of mass-effect, explaining the findings of raised intracranial pressure on cross-sectional brain imaging:</p><ul>
  • +<li>effacement of the ventricles, basal cisterns and other CSF spaces</li>
  • +<li>brain herniation</li>
  • +<li>loss of grey-white matter differentiation</li>
  • +</ul><h4>Treatment and complications</h4><p>Specific treatment relates to the underlying aetiology.</p><h5>Complications</h5><ul>
  • +<li>permanent loss of vision</li>
  • +<li>permanent loss of neurological functions</li>
  • +<li>death</li>

References changed:

  • 1. Mollan SP, Spitzer D, Nicholl DJ. Raised intracranial pressure in those presenting with headache. (2018) BMJ (Clinical research ed.). 363: k3252. <a href="https://doi.org/10.1136/bmj.k3252">doi:10.1136/bmj.k3252</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/30287521">Pubmed</a> <span class="ref_v4"></span>
  • 1. Mollan SP, Spitzer D, Nicholl DJ. Raised intracranial pressure in those presenting with headache. (2018) BMJ (Clinical research ed.). 363: k3252. <a href="https://doi.org/10.1136/bmj.k3252">doi:10.1136/bmj.k3252</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/30287521">Pubmed</a> <span class="ref_v4"></span>
  • 1. raised intracranial pressure in patients with headache

Systems changed:

  • Central Nervous System

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Intracranial hypertension
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