Sarcoidosis (musculoskeletal manifestations)
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Musculoskeletal manifestations of sarcoidosis occur in ~20% (range 4-38%) of patients with sarcoidosis, and include joint involvement, bone lesions, and muscular disease. Approximately 25% of patients with sarcoidosis have associated arthropathy.
Pathology
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joints: joint involvement in sarcoidosis
- radiographically identifiable pathology is rare
- can be acute occurring isolated or as part of the Löfgren syndrome
- less commonly chronic arthritis presenting as non-deforming granulomatous synovitis or deforming non-erosive arthritis (Jacoud's deformity)
- dactylitis and/or tenosynovitis
- commonest joints to be involved the ankles, knees, elbows, and wrists
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muscles: muscle involvement in sarcoidosis
- muscles involvement occurs around 50-80%, but symptomatic in only 0.5-2.5%, mostly when the diaphragm or extra-ocular muscles are involved
- can be chronic proximal myopathy or less commonly acute mimicking polymyositis
- nodular pattern myopathy manifest as single or multiple painful nodules
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bones: skeletal sarcoidosis
- hands are mainly affected
- lace-like patternof bone destruction in metaphysis, cystic bone lesions with well defined margins and lytic bone lesions with periosteal reaction
- remodelling of the cortex of phalanges, in which the concave shaft is converted into a tubular structure
- sclerotic bone lesions
- osteoapenia/osteoporosis
-<a title="osteoapaenia" href="/articles/osteoapaenia">osteoapenia</a>/<a title="Osteoporosis" href="/articles/osteoporosis-3">osteoporosis</a>- +<a href="/articles/osteoapaenia">osteoapenia</a>/<a href="/articles/osteoporosis-3">osteoporosis</a>
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