Spontaneous retropharyngeal hemorrhage

Spontaneous retropharyngeal haemorrhage, also known as spontaneous retropharyngeal haematoma, describes an accumulation of blood in the retropharyngeal space. It is a rare but potentially fatal entity due to potential for acute airway obstruction and/or rapid internal bleeding.

Epidemiology

Spontaneous retropharyngeal haemorrhage can occur in any age group and generally, there is no gender predominance. Certain predisposing factors (see Pathology section below) tend to occur more frequently in different age groups.

Clinical presentation

Common presenting complaints include sore throat mimicking pharyngitis, odynophagia, and dysphagia ^2,4. If the bleeding occurs quickly, progressive airway obstruction can develop. As these symptoms are nonspecificnon-specific, the clinical differential diagnoses arediagnosis is broad.

The classical signs of spontaneous retropharyngeal haemorrhage are included in the Capps triad ⁶.

Pathology

Spontaneous retropharyngeal haemorrhage dissects through the retropharyngeal space, which is composed mainly of loose areolar tissue and whose anterior border, the buccopharyngeal fascia, is bounded only by the air in the nasopharynx, oropharynx, and hypopharynx. As the haematoma fills this space, symptoms may be delayed by two to three hours ⁴. Should the haematoma become large enough, it may compress the airway and the oesophagus due to substantial internal blood loss.

Radiographic features

Plain radiograph

Anterior displacement of the trachea +/- posterior indentation due to the mass effect of the haematoma can be seen on a lateral neck radiograph.

CT

CT is the primary modality used in the diagnosis of retropharyngeal haemorrhage as patients usually present acutely and need urgent assessment and management in the emergency department. 

The retropharyngeal space is expanded by blood, which will be hyperdense in the acute phase. The pharynx superiorly and the oesophagus and trachea are displaced anteriorly and compressed. 

MRI

MRI appearance will vary depending on the rapidity of bleeding and age of the haematoma (see ageing of blood on MRI). In most instances cases will present fairly acutely with the following signal intensity in the retropharyngeal fluid ⁶:

• T1: hyperintense
• T2: hyperintense
• T2*/SWI: susceptibility-induced signal loss in parts of the collection
• DWI/ADC: variable

It is particularly important to recognise that blood can result in diffusion-weighted imaging signal characteristics that can mimic pus, with high b=1000 signal and low ADC values encountered; this is important as a retropharyngeal abscess is a common differential diagnosis. 

Treatment and prognosis

TheMost patients can be managed conservatively with observation, supportive treatment and radiological monitoring ⁵.

However, the proximity of the retropharyngeal space to the airway poses a serious threat to patency should a haemorrhage be rapidly expanding.

Previously it has been described that thereThere is no single consensus regarding theairway management of the airway ³. The haematoma may distort the anatomy of the airway, creating a challenge in securing it safety ⁴. While prophylactic endotracheal intubation or tracheostomy may be tempting to secure the airway, such measures may exacerbate bleeding, especially in anticoagulated patients ³.   

Most patients can be managed conservatively with observation, supportive treatment and radiological monitoring ⁵.

Surgical treatment should be avoided unless there is an identifiable treatable cause or compromise of the airway occurs (or is seemingly imminent) ⁴. Small or moderately sized haematomas canmay resolve with conservative management ⁴. While surgery does lead to earlier recovery and extubation, there is an increased risk of infection ⁵. 

Angiography and vessel embolisation may also be considered as an alternative and offers a number of advantages over surgical intervention; rapid access, short procedure time, ability to stem multiple sites of bleeding, ability to localise more superior origin of haemorrhage and a more selective therapeutic vessel occlusion not amendableamenable to open surgery ⁹⁸. 

Medical treatment comprises primarily of reversal of anticoagulation by withholding anticoagulants, and replacement of vitamin K and clotting factors ³. The use of steroids and antibiotics has also been reported but there is little evidence for their use ^4,9,8.