Gliomatosis cerebri

Case contributed by Assoc Prof Frank Gaillard

Patient Data

Age: 40-50

MRI Brain

Select images from MRI study depicting multiple foci of T2/FLAIR cortical and white matter signal abnormalities involving the left parietal and occipital lobes, as well as the basal ganglia and insula. There is no contrast enhancement. 

Case Discussion

This patient underwent a brain biopsy that revealed: infiltrating glioma, consistent with gliomatosis cerebri.

Based upon the histologic features noted in the small biopsies, this glioma would only qualify as an astrocytoma grade II/IV using the Dumas-Duport grading system. Because of the diffuse pattern of infiltration, and sampling, this probably does not accurately reflect the actual grade of this malignant glioma.

Importantly, whereas gliomatosis was previously considered a distinct entity, since the 2016 update to the WHO classification of CNS tumors it is now merely thought of as a growth pattern.

PlayAdd to Share

Case information

rID: 4367
Published: 14th Aug 2008
Last edited: 13th Aug 2019
Inclusion in quiz mode: Included

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.